Concept
Classe de différenciation
Publications associées (101)
Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics
Cells are the smallest operational units of living systems. Through synthesis of various biomolecules and exchange of signals with the environment, cells tightly regulate their composition to realize a specific functional state. The transformation of a cel ...
EPFL2024Characterization of the gut-bone marrow axis through bile acid signaling
Communication between the intestine and other organs such as the lungs, brain or bones is mediated by several metabolites, like short-chain fatty acids or bile acids, that relay information about nutritional and microbiota status. Bile acids are endogenous ...
EPFL2024Single-cell lipidomics reveals a role for cell-to-cell sphingolipid heterogeneity in fibroblast activation
Cell-to-cell variability plays a key role in tissue patterning by setting initial asymmetry that primes cell fate decisions. Fluctuations in the activity of regulatory molecules can commit individual cells to divergent differentiation pathways, and cell-to ...
EPFL2021Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link
Jacques Fellay, Christian Axel Wandall Thorball
Background: Considering the remaining threat of drug-resistantmutations (DRMs) to antiretroviral treatment (ART) efficacy, we investigated how the selective pressure of human leukocyte antigen (HLA)-restricted cytotoxic T lymphocytes drives certain DRMs' e ...
ELIFE SCIENCES PUBLICATIONS LTD2021Emerging functions of the nuclear receptor LRH-1 in liver physiology and pathology
Kristina Schoonjans, Hadrien Charles Edouard Demagny, Yu Sun
Nuclear receptors play pleiotropic roles in cell differentiation, development, proliferation, and metabolic processes to govern liver physiology and pathology. The nuclear receptor, liver receptor homolog-1 (LRH-1, NR5A2), originally identified in the live ...
2021HLA tapasin independence: broader peptide repertoire and HIV control
Human leukocyte antigen (HLA) class I allotypes vary in their ability to present peptides in the absence of tapasin, an essential component of the peptide loading complex. We quantified tapasin dependence of all allotypes that are common in European and Af ...
NATL ACAD SCIENCES2020