Concept

Thérapie génique de la rétine humaine

Publications associées (229)

Long-term in vivo impedance changes of subretinal microelectrodes implanted in dystrophic P23H rats

Retinal prostheses are being developed to restore vision in blind patients with photoreceptor degeneration. Electrodes arrays were subretinally implanted in transgenic P23H rats with their photoreceptors degenerated. Electrical stability of the implants wa ...

Wichtig Editore2013

A polymer-based interface restores light sensitivity in rat blind retinas

Diego Ghezzi

Sight restoration is one of the new frontiers for prosthetic devices that enable the electrical stimulation of neurons. In particular, diseases that affect the retinal pigment epithelium and photoreceptors but preserve the inner retinal layers are preferen ...

2013

Organic semiconductors for artificial vision

Diego Ghezzi

Organic semiconductors have emerged in the past two decades as promising materials for many technological applications. Thanks to their unique optoelectronic properties, they represent an ideal system to mimic natural photoreceptor functioning. This simila ...

2013

A polymer optoelectronic interface restores light sensitivity in blind rat retinas

Diego Ghezzi

Interfacing organic electronics with biological substrates offers new possibilities for biotechnology by taking advantage of the beneficial properties exhibited by organic conducting polymers. These polymers have been used for cellular interfaces in severa ...

2013

Direct and Retrograde Transduction of Nigral Neurons with AAV6, 8, and 9 and Intraneuronal Persistence of Viral Particles

Patrick Aebischer, Bernard Schneider

Recombinant adeno-associated viral (AAV) vectors of serotypes 6, 8, and 9 were characterized as tools for gene delivery to dopaminergic neurons in the substantia nigra for future gene therapeutic applications in Parkinson's disease. While vectors of all th ...

Mary Ann Liebert2013

Retinal and post-retinal contributions to the quantum efficiency of the human eye revealed by electrical neuroimaging

Enrico Pomarico, Nicolas Gisin

The retina is one of the best known quantum detectors with rods able to reliably respond to single photons. However, estimates on the number of photons eliciting conscious perception, based on signal detection theory, are systematically above these values ...

Frontiers Research Foundation2013

MAR Elements and Transposons for Improved Transgene Integration and Expression

Nicolas Mermod, Déborah Ley, Niamh Harraghy

Reliable and long-term expression of transgenes remain significant challenges for gene therapy and biotechnology applications, especially when antibiotic selection procedures are not applicable. In this context, transposons represent attractive gene transf ...

2013

ERK1/2 pathway is activated in degenerated Rpe65-deficient mice

The MAPK family is composed of three majors kinases, JNK, p38 and ERK1/2, and is implicated in many degenerative processes, including retinal cell death. The purpose of our study was to evaluate the activation of ERK1/2 kinase, and its potential role in Mu ...

Academic Press Ltd- Elsevier Science Ltd2013

Analysis of the Cytoprotective Role of alpha-Crystallins in Cell Survival and Implication of the alpha A-Crystallin C-Terminal Extension Domain in Preventing Bax-Induced Apoptosis

Séverine Hamann

alpha-Crystallins, initially described as the major structural proteins of the lens, belong to the small heat shock protein family. Apart from their function as chaperones, alpha-crystallins are involved in the regulation of intracellular apoptotic signals ...

Public Library of Science2013

Modeling dynamic aspects of human nonvisual responses to light

Marilyne Andersen, María Lovísa Ámundadóttir, Steven W. Lockley

Since 2002, when the first reports on the discovery of a novel type of mammalian ocular photoreceptor were published, a new field of study at the intersection of photobiology and architecture started to emerge. These novel non-rod, non-cone photoreceptors ...

2013

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