Concept

Structure secondaire d'un acide nucléique

Publications associées (135)

Interplay of Chemical and Electronic Structure on the Single-Molecule Level in 2D Polymerization

Klaus Kern, Claudius Morchutt, Carola Strasser

Single layers of covalently linked organic materials in the form of two-dimensional (2D) polymers constitute structures complementary to inorganic 2D materials. The electronic properties of 2D polymers may be manipulated through a deliberate choice of the ...

American Chemical Society2016

Toward an Effective Control of DNA's Submolecular Conformation on a Surface

Giovanni Dietler, Dusan Vobornik, Aleksandre Japaridze, Andrea Cerreta, Ewelina Wioletta Lipiec

DNA adopts different conformations based on its environment. We reveal conditions that either preserve the DNA's physiological B-conformation, even upon its placement in UHV, or lead to a partial B-form to A-form reorganization upon DNA's deposition on a s ...

American Chemical Society2016

Unraveling the weak hydrogen bonds of ethynylpyridines and ethynylbenzene with trimethylphosphate - A combined FT-Raman spectroscopic and quantum-chemical study

Tomislav Horvat

The interplay of secondary hydrogen bonds of 2- and 3-ethynylpyridine or ethynylbenzene with trimethylphosphate in tetrachloroethene was elucidated using FT-Raman spectroscopy and MP2/6-311 + G(d,p) calculations. The direct participation of C C moiety in t ...

Elsevier Science Bv2016

Shape-Persistent, Thermoresponsive Polypeptide Brushes Prepared by Vapor Deposition Surface-Initiated Ring-Opening Polymerization of alpha-Amino Acid N-Carboxyanhydrides

Harm-Anton Klok, Solenne Desseaux

Surface-grafting thermoresponsive polymers allows the preparation of thin polymer brush coatings with surface properties that can be manipulated by variation of temperature. In most instances, thermoresponsive polymer brushes are produced using polymers th ...

Amer Chemical Soc2015

Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation

Giovanni Dietler, Giovanni Longo, Francesco Simone Ruggeri, Ewelina Wioletta Lipiec

Amyloids are insoluble protein fibrillar aggregates. The importance of characterizing their aggregation has steadily increased because of their link to human diseases and material science applications. In particular, misfolding and aggregation of the Josep ...

Nature Publishing Group2015

New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods

Francesco Simone Ruggeri

Today, more than 40 million people worldwide are affected by neurodegenerative disorders. Onset of these diseases is associated with insoluble fibrillar protein aggregates, termed amyloids. The molecular origin and the link between amyloid formation and di ...

EPFL2015

Estimation of Divergence-Free 3D Cardiac Blood Flow in a Zebrafish Larva Using Multi-View Microscopy

Michael Stefan Daniel Liebling

Conventional fluid flow estimation methods for in vivo optical microscopy are limited to two-dimensions and are only able to estimate the components of flow parallel to the imaging plane. This limits the study of flow in more intricate biological structure ...

2015

Perturbations of the Straight Transmembrane alpha-Helical Structure of the Amyloid Precursor Protein Affect Its Processing by gamma-Secretase

Matteo Dal Peraro, Patrick Fraering, Mitko Dimitrov, Thomas Lemmin

Background: Amyloid- neurotoxicity depends on the specificity of the proteolytic cleavage of the amyloid precursor protein (APP) transmembrane domain. Results: The APP transmembrane -helix is straight in a biological membrane bilayer. Conclusion: The flexi ...

American Society for Biochemistry and Molecular Biology2014

Predicting the genes regulated by microRNAs via binding sites in the 3' untranslated and coding regions

Jiri Vanicek

MicroRNAs form one of the groups of small noncoding RNA molecules that have completely changed our understanding of gene regulatory networks. Because microRNAs have been discovered only relatively recently, most of their functions remain unknown, providing ...

Swiss Chemical Soc2014

Effect of Extended π-Conjugation of the Donor Structure of Organic D–A−π–A Dyes on the Photovoltaic Performance of Dye-Sensitized Solar Cells

Shaik Mohammed Zakeeruddin, Jacques-Edouard Moser, Robin Humphry-Baker, Magdalena Anna Marszalek, Takeru Bessho, Mateusz Barnaba Wielopolski

Two new D−A−π-spacer−A organic dyes, KM-10 and KM-11, containing a benzothiadiazole unit in a π-spacer and a cyanoacrylic acid as an acceptor have been synthesized and tested as sensitizers in dye-sensitized solar cells. Structural variations of the donor ...

Amer Chemical Soc2014

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