Publications associées à Télomérase

Myogenic potential of canine craniofacial satellite cells

The skeletal fibers have different embryological origin; the extraocular and jaw-closer muscles develop from prechordal mesoderm while the limb and trunk muscles from somites. These different origins characterize also the adult muscle stem cells, known as ...

Frontiers Research Foundation2014

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

Yi Zhang, Friedrich Beermann, Jie Zhang, Yuan Liu, Qian Zhang, Li Li, Ang Li, Ping Chen, Bo Zhou, Rong Wu

Autophagy is linked to cell death, yet the associated mechanisms are largely undercharacterized. We discovered that melanoma, which is generally resistant to drug-induced apoptosis, can undergo autophagic cell death with the participation of orphan nuclear ...

Nature Publishing Group2014

A quantitative telomeric chromatin isolation protocol identifies different telomeric states

Joachim Lingner, Romain Hamelin, Florence Armand, Diego Chiappe, Marc Moniatte, Eric Aeby, Larissa Grolimund

Telomere composition changes during tumourigenesis, aging and in telomere syndromes in a poorly defined manner. Here we develop a quantitative telomeric chromatin isolation protocol (QTIP) for human cells, in which chromatin is cross-linked, immunopurified ...

Nature Publishing Group2013

Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools

Joachim Lingner, Shruti Sharma

Telomeres, the ends of linear eukaryotic chromosomes, shorten due to incomplete DNA replication and nucleolytic degradation. Cells counteract this shortening by employing a specialized reverse transcriptase called telomerase, which uses deoxyribonucleoside ...

Genetics Soc Am2013

Molecular basis of telomere syndrome caused by CTC1 mutations

Joachim Lingner, Jana Majerská, Liuh-Yow Chen

Mutations in CTC1 lead to the telomere syndromes Coats Plus and dyskeratosis congenita (DC), but the molecular mechanisms involved remain unknown. CTC1 forms with STN1 and TEN1 a trimeric complex termed CST, which binds ssDNA, promotes telomere DNA synthes ...

Cold Spring Harbor Laboratory Press2013

Structure of active dimeric human telomerase

Joachim Lingner

Telomerase contains a large RNA subunit, TER, and a protein catalytic subunit, TERT. Whether telomerase functions as a monomer or dimer has been a matter of debate. Here we report biochemical and labeling data that show that in vivo-assembled human telomer ...

Nature Publishing Group2013

CST for the grand finale of telomere replication

Joachim Lingner, Liuh-Yow Chen

Telomeric DNA at eukaryotic chromosome ends terminates with single stranded 3' G-rich overhangs. The overhang is generated by the interplay of several dynamic processes including semiconservative DNA replication, 3' end elongation by telomerase, C-strand f ...

Landes Bioscience2013

A three-state model for the regulation of telomerase by TERRA and hnRNPA1

Joachim Lingner, Sophie Redon, Ivo Zemp

Telomeres, the physical ends of eukaryotic chromosomes, are transcribed into telomeric repeat-containing RNA (TERRA), a large non-coding RNA, which forms an integral part of telomeric heterochromatin. In vitro, naked TERRA molecules are efficient inhibitor ...

Oxford University Press2013

Replication of Telomeres and the Regulation of Telomerase

Joachim Lingner, Verena Pfeiffer

Telomeres are the physical ends of eukaryotic chromosomes. They protect chromosome ends from DNA degradation, recombination, and DNA end fusions, and they are important for nuclear architecture. Telomeres provide a mechanism for their replication by semico ...

Cold Spring Harbor Lab Press, Publications Dept2013

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Télomérase

Myogenic potential of canine craniofacial satellite cells

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

A quantitative telomeric chromatin isolation protocol identifies different telomeric states

Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools

A Quantitative Telomeric Chromatin Isolation Protocol (Q-TIP) to Characterize Telomere Composition Changes

Molecular basis of telomere syndrome caused by CTC1 mutations

Structure of active dimeric human telomerase

CST for the grand finale of telomere replication

A three-state model for the regulation of telomerase by TERRA and hnRNPA1

Replication of Telomeres and the Regulation of Telomerase

Graph Chatbot

Chattez avec Graph Search

A quantitative telomeric chromatin isolation protocol identifies different telomeric states

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

CST for the grand finale of telomere replication

Myogenic potential of canine craniofacial satellite cells

A Quantitative Telomeric Chromatin Isolation Protocol (Q-TIP) to Characterize Telomere Composition Changes

Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools

Structure of active dimeric human telomerase

Replication of Telomeres and the Regulation of Telomerase

A three-state model for the regulation of telomerase by TERRA and hnRNPA1

Molecular basis of telomere syndrome caused by CTC1 mutations