Concept
Télomérase
Publications associées (104)
Biologically active secondary metabolites from cyanobacteria
For millennia, nature was the only source of medicine for mankind. Even today natural products represent a large proportion of the drugs in use. In some areas, like cancer or infectious diseases, about 50 % of the compounds used are of natural origin. Cyan ...
EPFL2010Functional differentiation of tbf1 orthologues in fission and budding yeasts
In Saccharomyces cerevisiae, TBF1, an essential gene, influences telomere function but also has other roles in the global regulation of transcription. We have identified a new member of the tbf1 gene family in the mammalian pathogen Pneumocystis carinii. W ...
2009The Rat1p 5’ to 3’ exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae
Joachim Lingner, Sophie Redon, Andrea Bernardo Panza, Nahid Iglesias
Vertebrate telomeres are transcribed into telomeric repeat-containing RNA (TERRA) that associates with telomeres and may be important for telomere function. Here, we demonstrate that telomeres are also transcribed in Saccharomyces cerevisiae by RNA polymer ...
2008Controlled Exchange of Chromosomal Arms Reveals Principles Driving Telomere Interactions in Yeast
The 32 telomeres in the budding yeast genome cluster in three to seven perinuclear foci. Although individual telomeres and telomeric foci are in constant motion, preferential juxtaposition of some telomeres has been scored. To examine the principles that g ...
Cold Spring Harbor Laboratory Press2008Low- to high-throughput analysis of telomerase modulators with Telospot
Joachim Lingner, Gerardo Turcatti, Marc Chambon, Damiano Banfi
We designed a method termed Telospot to discover and characterize telomerase modulators as anticancer drugs or chemical biology tools. Telospot is based on a highly efficient human telomerase expression system and the detection of telomerase DNA reaction p ...
2007