Concept
Inhibiteur de l'enzyme de conversion
Publications associées (50)
Effect of the structural modification of Candesartan with Zinc on hypertension and left ventricular hypertrophy
Nikolaos Stergiopoulos, Augusto Martins Lima, Valeria Romina Martinez
Hypertension is the most common cause of left ventricular hypertrophy, contributing to heart failure progression. Candesartan (Cand) is an angiotensin receptor antagonist widely used for hypertension treatment. Structural modifications were previously perf ...
ELSEVIER2023Kidney-Specific CAP1/Prss8-Deficient Mice Maintain ENaC-Mediated Sodium Balance through an Aldosterone Independent Pathway
The serine protease prostasin (CAP1/Prss8, channel-activating protease-1) is a confirmed in vitro and in vivo activator of the epithelial sodium channel ENaC. To test whether proteolytic activity or CAP1/Prss8 abundance itself are required for ENaC activat ...
MDPI2022p-Aminobenzamidine attenuates cardiovascular dysfunctions in spontaneously hypertensive rats
Nikolaos Stergiopoulos, Fabiana Pereira Da Costa Fraga, Allancer Divino De Carvalho Nunes
Aims:Diminazene aceturate, a putative ACE2 activator, is susceptible to cleavage resulting in the formation of paminobenzamidine (PAB). This study aimed to investigate the effects of PAB in addressing cardiovascular dysfunctions in spontaneously hypertensi ...
PERGAMON-ELSEVIER SCIENCE LTD2022Rational design of protein switches: applications in synthetic biology and cancer immunotherapy
Synthetic biology aims to engineer cells as miniature biological devices to sense, process, and respond to exogenous stimuli. Protein switches are designed to sense and respond to various molecular queues in a fast and specific manner, which fits the requi ...
EPFL2022