Daniel ConstamDaniel Constam received his doctoral degree in Natural Sciences from ETH Zürich in the neuroimmunology group of Adriano Fontana (1993). For postdoctoral studies, he joined the laboratory of Elizabeth Robertson as an EMBO fellow at Harvard University to characterize proprotein convertase (PC) functions in mouse models of early embryogenesis (1994-1999). As an ISREC group leader (>2000) and Associate Professor at EPFL (>2007), he initially continued to study pluripotency and lineage differentiation during development and found that several secreted PCs jointly regulate cell-cell adhesion and TGFβ signaling pathways at the cross-roads of stem cell and cancer biology. To map the proteolytic activity of PCs and their relative distribution in exocytic or endocytic vesicles, his lab developed PC-specific FRET sensors for high resolution live imaging in normal cells and in tumour-host interactions. His studies on TGFβ signaling also identified the RNA-binding protein Bicc1 and its self-polymerization in membrane-less organelles as regulators of mRNA translation and cell metabolism that cooperate with primary cilia to prevent cystic growth in renal tubules and in pancreatic and bile ducts.
Priscilla TurelliPositions
2005-présent: Chercheur, Ecole Polytechnique Fédérale de Lausanne, Laboratoire de virologie et génétique, Suisse.
2001-2004: Chercheur dans le laboratoire du Pr D. Trono, Département de Microbiologie, Ecole de Médecine de Genève, Suisse.
1997-2001: Etudiante Post-doctorante dans le laboratoire du Pr D. Trono, Département de Microbiologie, Ecole de Médecine de Genève, Suisse.
Honneurs et prix
2004: Bristol-Myers Squibb AIDS AWARD
1997-1999: Human Frontier Science Program fellowship
Education
June 1997:
PhD in cellular biology.
Final mark:jury congratulations.
Université de la Méditerranée, France.
June 1993:
Post-graduate diploma in cellular biology and microbiology.
INSERM U372, Marseille-Luminy, université de Provence, France.
June 1992:
Master in cellular biology Specialty: genetic.
Final mark: Best master student of this year.
Université de la Méditerranée, France.
June 1987:
Scientific baccalaureate, France.
Enseignement
2009-présent: co-directeur de thèses, Ecole Polytechnique Fédérale de Lausanne, Suisse
2002: Tuteur en virologie pour les étudiants de médecine, Ecole de Médecine de Genève, Suisse.
1996-1997: Tuteur en biologie moléculaire et biochimie, Université de la Méditerranée, Aix Marseille II 