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Publications associées (22)
Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression
Pierre Magistretti, Jean-René Cardinaux
Recent studies implicate the arginine-decarboxylation product agmatine in mood regulation. Agmatine has antidepressant properties in rodent models of depression, and agmatinase (Agmat), the agmatine-degrading enzyme, is upregulated in the brains of mood di ...
Nature Publishing Group2016Peripubertal stress-induced behavioral changes are associated with altered expression of genes involved in excitation and inhibition in the amygdala
Maria del Carmen Sandi Perez, Stamatina Tzanoulinou, Orbicia Riccio Wicht
Early-life stress is a critical risk factor for developing psychopathological alterations later in life. This early adverse environment has been modeled in rats by exposure to stress during the peripubertal period-that is, corresponding to childhood and pu ...
Nature Publishing Group2014Acute systemic rapamycin induces neurobehavioral alterations in rats
Rapamycin is a drug with antiproliferative and immunosuppressive properties, widely used for prevention of acute graft rejection and cancer therapy. It specifically inhibits the activity of the mammalian target of rapamycin (mTOR), a protein kinase known t ...
Elsevier Science Bv2014Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression
Pierre Magistretti, Maria del Carmen Sandi Perez, Didier Trono, Maria Isabel Cordero Campana, Guillaume Poirier, Anna Claire Groner, Cristina Marquez Vega
Although adverse early life experiences have been found to increase lifetime risk to develop violent behaviors, the neurobiological mechanisms underlying these long-term effects remain unclear. We present a novel animal model for pathological aggression in ...
Nature Publishing Group2013Special Section on Social Media as Sensors
Social media have transformed the Web into an interactive sharing platform where users upload data and media, comment on, and share this content within their social circles. Each content item is associated with an abundance of metadata and related informat ...
Ieee-Inst Electrical Electronics Engineers Inc2013Hippocampal neuroligin-2 overexpression leads to reduced aggression and inhibited novelty reactivity in rats
Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Orbicia Riccio Wicht, Céline Fournier
Disturbances of the excitation/inhibition (E/I) balance in the brain were recently suggested as potential factors underlying disorders like autism and schizophrenia resulting in associated behavioral alterations including changes in social and emotional be ...
Public Library of Science2013Psychobiological Vulnerability to Stress
Maria del Carmen Sandi Perez, Jorge Eduardo Castro Cifuentes
Several psychobiological factors are associated with vulnerability/resilience to stress-induced depression. Emerging evidence indicates behavioral traits, such as anxiety, can be related to depression-like symptoms after exposure to chronic stress. However ...
EPFL2012Deletion of CREB-Regulated Transcription Coactivator 1 Induces Pathological Aggression, Depression-Related Behaviors, and Neuroplasticity Genes Dysregulation in Mice
Jean-René Cardinaux, Christophe Mérinat
Background: Mood disorders are polygenic disorders in which the alteration of several susceptibility genes results in dysfunctional mood regulation. However, the molecular mechanisms underlying their transcriptional dysregulation are still unclear. The tra ...
Elsevier Science Inc2012Prefrontal Plasticity and Stress Inoculation-Induced Resilience
Coping with mild early life stress tends to make subsequent coping efforts more effective and therefore more likely to be used as a means of arousal regulation and resilience. Here we show that this developmental learning-like process of stress inoculation ...
2009