Concept

Immunization

Publications associées (26)

Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization

Philippe Colin, Aleksandar Antanasijevic

Neutralizing antibodies (NAbs) to multiple epitopes on the HIV-1-envelope glycoprotein (Env) have been isolated from infected persons. The potency of NAbs is measured more often than the size of the persistent fraction of infectivity at maximum neutralizat ...

San Francisco2023

Leukocyte count is associated with coronary artery disease (CAD) events in the general population. Here we show that leukocytes are independently associated with CAD events in people with HIV in Switzerland, after adjusting for traditional and HIVrelated r ...

OXFORD UNIV PRESS INC2023

Immunizing Systems from Distant Failures by Limiting Lamport Exposure

Bryan Alexander Ford, Cristina Basescu

Failures far away from a user should intuitively be less likely to affect that user. Today's ecosystem miserably fails this test, however, despite high-availability best practices. Correlated and cascading failures – triggered by misconfigurations, bugs, a ...

Association for Computing Machinery2021

On the exploration of novel methodological approaches for immunogen design: case studies in influenza and hepatitis C

Andreas Scheck

Proteins are fundamental components in biological systems and crucial for a variety of biological functions. Over the last decades, significant progress in structural biology has facilitated the study of proteins and their interactions with molecular partn ...

EPFL2021

Contact networks across ages: computational analysis of epidemiological dynamics

Gianrocco Lazzari

For decades mathematical modeling in epidemiology has helped understanding the dynamics of infectious diseases, as well as describe possible intervention scenarios to prevent and control them. However, such models were relying on several assumptions, such ...

EPFL2020

Hexachlorobenzene exerts genotoxic effects in a humpback whale cell line under stable exposure conditions

Kristin Schirmer, Jenny Maner

Humpback whales, like other polar wildlife, accumulate persistent organic pollutants. In Southern hemisphere populations, hexachlorobenzene (HCB) dominates the contaminant profiles. HCB is linked to a variety of health effects and is classified as a group ...

ROYAL SOC CHEMISTRY2019

Interplay between cost and benefits triggers nontrivial vaccination uptake

Paolo De Los Rios, Alessio Vincenzo Cardillo

The containment of epidemic spreading is a major challenge in science. Vaccination, whenever available, is the best way to prevent the spreading, because it eventually immunizes individuals. However, vaccines are not perfect, and total immunization is not ...

2018

Benefit of vaccination in protecting the departments of Grand’Anse, Ouest and Sud against a potential second epidemic wave of cholera

Andrea Rinaldo, Enrico Bertuzzo, Flavio Finger, Damiano Pasetto

In a previous report, we presented model projections based on data available up to epi-week 43 (ending Oct-29). These projections suggested that, due to anticipated heavy rainfalls at the end of November, a second peak of cholera might be observed in early ...

Epicentre2016

The lymphatic system serves a critical role in fluid homeostasis, lipid metabolism and immune surveillance. The growing appreciation of its implication in various diseases challenges the conventional view of lymphatics as a passive transport system. Tradit ...

EPFL2016

Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System

Bernard Schneider, Aurélien Lathuilière

Ex vivo gene therapy using retrievable encapsulated cellular implants is an effective strategy for the local and/or chronic delivery of therapeutic proteins. In particular, it is considered an innovative approach to modulate the activity of the immune syst ...

MDPI2015

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