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Publications associées (19)
A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy
Jacques Fellay, Flavia Aurelia Shoko Hodel
Infectious agents contribute significantly to the global burden of diseases through both acute infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci that influence humoral immune response to multiple infections. From 45 ...
Cambridge2024Biotechnological Frontiers of DNA Nanomaterials Continue to Expand: Bacterial Infection using Virus-Inspired Capsids
Maartje Martina Cornelia Bastings
The elegant geometry of viruses has inspired bio-engineers to synthetically explore the self-assembly of polyhedral capsids employed to protect new cargo or change an enzymatic microenvironment. Recently, Yang and co-workers used DNA nanotechnology to revi ...
WILEY-V C H VERLAG GMBH2023Material Substrate Physical Properties Control Pseudomonas aeruginosa Biofilm Architecture
Alexandre Louis André Persat, Alice Cont
The biofilm lifestyle is the most widespread survival strategy in the bacterial world. Pseudomonas aeruginosa biofilms cause chronic infections and are highly recalcitrant to antimicrobials. The genetic requirements allowing P. aeruginosa to grow into biof ...
AMER SOC MICROBIOLOGY2023Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14
A key attribute of persistent or recurring bacterial infections is the ability of the pathogen to evade the host's immune response. Many Enterobacteriaceae express type 1 pili, a pre-adapted virulence trait, to invade host epithelial cells and establish pe ...
eLIFE SCIENCES PUBL LTD2022PD-1-cis IL-2R agonism yields better effectors from stem-like CD8(+) T cells
Douglas Hanahan, Mélanie Louise Tichet, Petra Catalina Schwalie, Stephan Wullschleger, Maria Karagianni
Expansion and differentiation of antigen-experienced PD-1(+)TCF-1(+) stem-like CD8(+) T cells into effector cells is critical for the success of immunotherapies based on PD-1 blockade(1-4). Hashimoto et al. have shown that, in chronic infections, administr ...
NATURE PORTFOLIO2022The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity
Contemporary genomic approaches allow us to seek answers to biological questions that were previously out of reach. Genome-wide association studies (GWAS) have identified numerous genetic polymorphisms associated with human diseases, providing new insight ...
EPFL2022Rapid Multianalyte Microfluidic Homogeneous Immunoassay on Electrokinetically Driven Beads
Carlotta Guiducci, Pierre-Emmanuel Marie Thiriet, Gloria Porro, Danashi Imani Medagoda
The simplicity of homogeneous immunoassays makes them suitable for diagnostics of acute conditions. Indeed, the absence of washing steps reduces the binding reaction duration and favors a rapid and compact device, a critical asset for patients experiencing ...
2020Immuno-affinity Amperometric Detection of Bacterial Infections
Hubert Girault, Horst Pick, Andreas Stephan Lesch, Michel Prudent, Milica Jovic, Yingdi Zhu
A combination of an immuno-affinity enrichment strategy and sensitive amperometric read-out was implemented in a point-of-care platform intended for bacterial infection analysis. Bacterial cells, selectively captured and enriched from complex matrices thro ...
WILEY-V C H VERLAG GMBH2018Assessment of shear stress related parameters in the carotid bifurcation using mouse-specific FSI simulations
The ApoE(-/-) mouse is a common small animal model to study atherosclerosis, an inflammatory disease of the large and medium sized arteries such as the carotid artery. It is generally accepted that the wall shear stress, induced by the blood flow, plays a ...
Elsevier Sci Ltd2016Type I Interferon Signaling Prevents IL-1 beta-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue
Type I interferons (IFN-Is) are fundamental for antiviral immunity, but their role in bacterial infections is contradictory and incompletely described. Streptococcus pyogenes activates IFN-I production in innate immune cells, and IFN-I receptor 1 (Ifnar1)- ...
Cell Press2016