Concept
Myelin basic protein
Publications associées (23)
Multiparametric Characterization and Spatial Distribution of Different MS Lesion Phenotypes
Tobias Kober, Tom Hilbert, Gian Franco Piredda
BACKGROUND AND PURPOSE: MS lesions exhibit varying degrees of axonal and myelin damage. A comprehensive description of lesion phenotypes could contribute to an improved radiologic evaluation of smoldering inflammation and remyelination processes. This stud ...
Amer Soc Neuroradiology2024Signatures of life course socioeconomic conditions in brain anatomy
Maria del Carmen Sandi Perez, Bogdan Draganski
Socioeconomic status (SES) plays a significant role in health and disease. At the same time, early-life conditions affect neural function and structure, suggesting the brain may be a conduit for the biological embedding of SES. Here, we investigate the bra ...
2022Measuring compartmental T-2-orientational dependence in human brain white matter using a tiltable RF coil and diffusion-T-2 correlation MRI
The anisotropy of brain white matter microstructure manifests itself in orientational-dependence of various MRI contrasts, and can result in significant quantification biases if ignored. Understanding the origins of this orientation-dependence could enhanc ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2021The Inequality of Neural Destiny: Signatures of Lifecourse Socioeconomic Conditions in Markers of Brain Tissue Myelination and Volume
Maria del Carmen Sandi Perez, Bogdan Draganski, Leyla Loued-Khenissi
Socioeconomic status (SES) plays a significant role in health and disease. At the same time, early-life conditions affect neural function and structure, suggesting the brain may be a conduit for the biological embedding of SES. Here, we investigate the neu ...
2020Model-informed machine learning for multi-component T2 relaxometry
Jean-Philippe Thiran, Meritxell Bach Cuadra, Tobias Kober, Tom Hilbert, Erick Jorge Canales Rodriguez, Elda Fischi Gomez, Marco Pizzolato, Gian Franco Piredda, Thomas Yu, Cristina Granziera, Muhamed Barakovic
Recovering the distribution from multi-echo magnetic resonance (MR) signals is challenging but has high potential as it provides biomarkers characterizing the tissue micro-structure, such as the myelin water fraction (MWF). In this work, we propose to comb ...
2020Repetitive Erythropoietin Treatment Improves Long-Term Neurocognitive Outcome by Attenuating Hyperoxia-Induced Hypomyelination in the Developing Brain
Introduction:Preterm infants born before 28 weeks of gestation are at high risk of neurodevelopmental impairment in later life. Cerebral white and gray matter injury is associated with adverse outcomes. High oxygen levels, often unavoidable in neonatal int ...
FRONTIERS MEDIA SA2020Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice
Maurizio Molinari, Francesca Bianchi
In the peripheral nervous system (PNS) myelinating Schwann cells synthesize large amounts of myelin protein zero (P0) glycoprotein, an abundant component of peripheral nerve myelin. In humans, mutations in P0 cause the demyelinating Charcot-Marie-Tooth 1B ...
2019