Concept
Conjugué anticorps-médicament
Publications associées (7)
Rational Design of Chemically Controlled Antibodies and Protein Therapeutics
Li Tang, Bruno Emanuel Ferreira De Sousa Correia, Sandrine Madeleine Suzanne Georgeon, Pablo Gainza Cirauqui, Anthony Marchand, Leo Scheller, Lucia Bonati, Stéphane Rosset, Sailan Shui
Protein-based therapeutics, such as monoclonal antibodies and cytokines, are important therapies for various pathophysiological conditions such as oncology, autoimmune disorders, and viral infections. However, the wide application of such protein therapeut ...
2023Surface engineering of T cells with polymer nanoparticles to enhance drug delivery to the brain
Firstly, this thesis presents the in vivo evaluation of a previously developed model system that utilizes CD4+ TE/M cells decorated with up to 100 polystyrene based nanoparticles per cell by maleimide thiol conjugation. These nanoparticle T-cell conjugates ...
EPFL2020Computational characterisation of the selectivity and binding mode of mono- and binuclear transition metal based anticancer compounds
Thibaud Edouard Alistair von Erlach
The rising resistance and the severe side effects associated with classical anticancer drugs such as cisplatin or mercaptopurines has triggered the development of novel antitumourous agents based on transition metal (e.g. ruthenium, osmium, and gold) organ ...
EPFL2020Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells
The goal of targeted cancer therapies is to specifically block oncogenic signalling, thus maximising efficacy, while reducing side-effects to patients. The gamma-secretase (GS) complex is an attractive therapeutic target in haematological malignancies and ...
Springer2014Synthetic Studies on Daphmanidin C and Maytenone Based on Biosynthetic Considerations and Natural Product Hybrids as Tools for Quorum Sensing
The isolation and characterisation of natural products remains a challenge in chemistry owing to nature's magnificent diversity. Natural products or natural product derivatives have always been used in traditional medicine to treat a variety of diseases. T ...
EPFL2010Interaction of Functionalized Superparamagnetic Iron Oxide Nanoparticles with Brain Structures
Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) com-bined with magnetic resonance imaging (MRI) are under clinical evaluation to enhance detection of neurodegenerative diseases. A major improvement would be to link therapeutic drugs to the SPIONs to a ...
2006