Publications associées à Transforming growth factor beta

Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania

The Mycobacterium tuberculosis complex (MTBC) comprises nine human-adapted lineages that differ in their geographical distribution. Local adaptation of specific MTBC genotypes to the respective human host population has been invoked in this context. We aim ...

Nature Portfolio2024

Mountaintop Gamma Ray Observations of Three Terrestrial Gamma‐Ray Flashes at the Säntis Tower, Switzerland With Coincident Radio Waveforms

Marcos Rubinstein, Antonio Sunjerga, Farhad Rachidi-Haeri, Amirhossein Mostajabi

We report on the mountain top observation of three terrestrial gamma-ray flashes (TGFs) that occurred during the summer storm season of 2021. To our knowledge, these are the first TGFs observed in a mountaintop environment and the first published European ...

2024

Regulation and function of a hemicleaved Activin-A processing intermediate in melanoma

Manon Bulliard

Activin-A is a Transforming Growth Factor-B (TGFB)-related cytokine that regulates various biological processes including cell proliferation and differentiation through autocrine, paracrine or endocrine signaling. Activin-A expression is upregulated in mul ...

EPFL2023

Acute TNF alpha levels predict cognitive impairment 6-9 months after COVID-19 infection

Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Alexandre Cionca, Idris Guessous

Background: A neurocognitive phenotype of post-COVID-19 infection has recently been described that is characterized by a lack of awareness of memory impairment (i.e., anosognosia), altered functional connectivity in the brain's default mode and limbic netw ...

PERGAMON-ELSEVIER SCIENCE LTD2023

Type I IFNs link skin-associated dysbiotic commensal bacteria to pathogenic inflammation and angiogenesis in rosacea

Alessio Mylonas, Yichen Wang, Jiaqi Chen

Rosacea is a common chronic inflammatory skin disease with a fluctuating course of excessive inflammation and apparent neovascularization. Microbial dysbiosis with a high density of Bacillus oleronius and increased activity of kallikrein 5, which cleaves c ...

AMER SOC CLINICAL INVESTIGATION INC2023

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Jacques Fellay, Christian Axel Wandall Thorball, Alessandro Borghesi, Yu Zhang, Peng Zhang, Qian Zhang

Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs) 1,2 , conferring a predisposition to life-threatening COVID-19 pneumonia 3 . ...

Nature Portfolio2023

Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner

Nicola Harris, Mario Michael Zaiss, Julia Esser-von Bieren, Lalit Kumar Dubey, Luc Xavier Marie Lebon

Approximately 2 billion people worldwide and a significant part of the domestic livestock are infected with soil-transmitted helminths, of which many establish chronic infections causing substantial eco-nomic and welfare burdens. Beside intensive research ...

2022

Differential impact of TGF beta/SMAD signaling activity elicited by Activin A and Nodal on endoderm differentiation of epiblast stem cells

Pierre Osteil

Allocation of cells to an endodermal fate in the gastrulating embryo is driven by Nodal signaling and consequent activation of TGF beta pathway. In vitro methodologies striving to recapitulate the process of endoderm differentiation, however, use TGF beta ...

WILEY2022

The matricellular protein Drosophila Cellular Communication Network Factor is required for synaptic transmission and female fertility

Evelyne Ruchti, Brian Donal McCabe

Within the extracellular matrix, matricellular proteins are dynamically expressed nonstructural proteins that interact with cell surface receptors, growth factors, and proteases, as well as with structural matrix proteins. The cellular communication networ ...

Genetics Society America2022

Non-genomic activation of the AKT-mTOR pathway by the mitochondrial stress response in thyroid cancer

Johan Auwerx, Kristina Schoonjans, Dongryeol Ryu

Cancer progression is associated with metabolic reprogramming and causes significant intracellular stress; however, the mechanisms that link cellular stress and growth signalling are not fully understood. Here, we identified a mechanism that couples the mi ...

2022