Concept

Transforming growth factor beta

Publications associées (142)

Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes

Embryonal Rhabdomyosarcoma (ERMS) and Undifferentiated Pleomorphic Sarcoma (UPS) are distinct sarcoma subtypes. Here we investigate the relevance of the satellite cell (SC) niche in sarcoma development by using Hepatocyte Growth Factor (HGF) to perturb the ...

Elife Sciences Publications Ltd2016

Extracellular matrix-inspired growth factor delivery systems for bone regeneration

Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez

Growth factors are very promising molecules to enhance bone regeneration. However, their translation to clinical use has been seriously limited, facing issues related to safety and cost-effectiveness. These problems derive from the vastly supra-physiologic ...

Elsevier Science Bv2015

MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and KRAS genes

Yiming Cao

Recent advances in cancer biology have emerged important roles for microRNAs (miRNAs) in regulating tumor responses. However, their function in mediating intercellular communication within the tumor microenvironment is thus far poorly explored. Here, we fo ...

Nature Publishing Group2015

Diminazene enhances stability of atherosclerotic plaques in ApoE-deficient mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Maiia Bragina

Angiotensin (Ang) II contributes to the development of atherosclerosis, while Ang-(1-7) has atheroprotective actions. Accordingly, angiotensin-converting enzyme 2 (ACE2), which breaks-down Aug 11 and forms Ang-(1-7), has been suggested as a target against ...

Elsevier2015

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

Stewart Cole, Andrea Ablasser, Muhammet Fatih Gülen, Sonia Garcia Perin, Claudia Sala, Jan Lars Rybniker, Ye Lou

Cytosolic detection of microbial products is essential for the initiation of an innate immune response against intracellular pathogens such as Mycobacterium tuberculosis (Mtb). During Mtb infection of macrophages, activation of cytosolic surveillance pathw ...

Cell Press2015

Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis

Olivier Martin, Gerardo Turcatti, Nicolas Jean Philippe Guex, Marc Chambon

The Wnt pathway, which controls crucial steps of the development and differentiation programs, has been proposed to influence lipid storage and homeostasis. In this paper, using an unbiased strategy based on high-content genome-wide RNAi screens that monit ...

Nature Publishing Group2015

BactImAS: a platform for processing and analysis of bacterial time-lapse microscopy movies

Zeljka Maglica

Background: The software available to date for analyzing image sequences from time-lapse microscopy works only for certain bacteria and under limited conditions. These programs, mostly MATLAB-based, fail for microbes with irregular shape, indistinct cell d ...

Biomed Central Ltd2014

Regulation of TGF beta and related signals by precursor processing

Daniel Constam

Secreted cytokines of the TGF beta family are found in all multicellular organisms and implicated in regulating fundamental cell behaviors such as proliferation, differentiation, migration and survival. Signal transduction involves complexes of specific ty ...

Elsevier2014

Transforming Growth Factor beta/Activin Signaling Functions as a Sugar-Sensing Feedback Loop to Regulate Digestive Enzyme Expression

Bruno Lemaitre, Maroun Bou Sleiman, Wen Bin Chng

Organisms need to assess their nutritional state and adapt their digestive capacity to the demands for various nutrients. Modulation of digestive enzyme production represents a rational step to regulate nutriment uptake. However, the role of digestion in n ...

Elsevier2014

The Mucosal Adjuvant Cholera Toxin B Instructs Non-Mucosal Dendritic Cells to Promote IgA Production Via Retinoic Acid and TGF-β

Nicola Harris

It is currently unknown how mucosal adjuvants cause induction of secretory immunoglobulin A (IgA), and how T cell-dependent (TD) or -independent (TI) pathways might be involved. Mucosal dendritic cells (DCs) are the primary antigen presenting cells driving ...

Public Library of Science2013

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