Publications associées à Lipogenèse

Hippo-YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass

Johan Auwerx, Xiaoxu Li, Jun Yong Kim, Maroun Bou Sleiman, Yoo Hoon Kim

Adipose tissues serve as an energy reservoir and endocrine organ, yet the mechanisms that coordinate these functions remain elusive. Here, we show that the transcriptional coregulators, YAP and TAZ, uncouple fat mass from leptin levels and regulate adipocy ...

Nature Portfolio2024

Evidence for a neuromuscular circuit involving hypothalamic interleukin-6 in the control of skeletal muscle metabolism

Vera Monica Lemos Da Silva, Ludger Jan Elzuë Goeminne, Barbara Moreira Crisol, Eduardo Rochete Ropelle

Hypothalamic interleukin-6 (IL6) exerts a broad metabolic control. Here, we demonstrated that IL6 activates the ERK1/2 pathway in the ventromedial hypothalamus (VMH), stimulating AMPK/ACC signaling and fatty acid oxidation in mouse skeletal muscle. Bioinfo ...

2022

Assessment of Aspartate and Bicarbonate Produced From Hyperpolarized [1-13C]Pyruvate as Markers of Renal Gluconeogenesis

Arnaud Comment, Hikari Ananda Infinity Yoshihara

As both a consumer and producer of glucose, the kidney plays a significant role in glucose homeostasis. Measuring renal gluconeogenesis requires invasive techniques, and less invasive methods would allow renal gluconeogenesis to be measured more routinely. ...

2021

The DEAD-box RNA helicase CshA is required for fatty acid homeostasis inStaphylococcus aureus

Bianca Marie Petrignani

Staphylococcus aureusis an opportunistic pathogen that can grow in a wide array of conditions: on abiotic surfaces, on the skin, in the nose, in planktonic or biofilm forms and can cause many type of infections. Consequently,S.aureusmust be able to adapt r ...

PUBLIC LIBRARY SCIENCE2020

PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

Johan Auwerx, Hao Li, Daniel Garcia

Rapid alterations in cellular metabolism allow tissues to maintain homeostasis during changes in energy availability. The central metabolic regulator acetyl-CoA carboxylase 2 (ACC2) is robustly phosphorylated during cellular energy stress by AMP-activated ...

CELL PRESS2020

Structural basis for regulation of human acetyl-CoA carboxylase

Henning Paul-Julius Stahlberg, Yakir Guri

Acetyl-CoA carboxylase catalyses the ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis(1,2). Eukaryotic acetyl-CoA carboxylases are large, homodimeric multienzymes. Human acetyl-CoA carboxylase occurs in two isoform ...

Springer Nature2018

Transforming Growth Factor beta/Activin signaling in neurons increases susceptibility to starvation

Bruno Lemaitre, Wen Bin Chng, Xiaoxue Li

Animals rely on complex signaling network to mobilize its energy stores during starvation. We have previously shown that the sugar-responsive TGF beta/Activin pathway, activated through the TGF beta ligand Dawdle, plays a central role in shaping the post-p ...

2017

Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease

Kristina Schoonjans, Vera Monica Lemos Da Silva, Hadrien Charles Edouard Demagny, Dongryeol Ryu, Xu Wang, Matthias Alexander Sokrates Stein, Maaike Hélène Oosterveer, Pan Xu

Hepatic steatosis is caused by metabolic imbalances that could be explained in part by an increase in de novo lipogenesis that results from increased sterol element binding protein 1 (SREBP-1) activity. The nuclear receptor liver receptor homolog 1 (LRH-1) ...

Amer Soc Clinical Investigation Inc2017

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Lipogenèse

Hippo-YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass

Evidence for a neuromuscular circuit involving hypothalamic interleukin-6 in the control of skeletal muscle metabolism

Assessment of Aspartate and Bicarbonate Produced From Hyperpolarized [1-13C]Pyruvate as Markers of Renal Gluconeogenesis

The DEAD-box RNA helicase CshA is required for fatty acid homeostasis inStaphylococcus aureus

PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

Novel Molecular Probes for Non-invasive Optical Imaging of Fatty Acid and Triglyceride Uptake in Living Animals

Structural basis for regulation of human acetyl-CoA carboxylase

Transforming Growth Factor beta/Activin signaling in neurons increases susceptibility to starvation

Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease

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Chattez avec Graph Search

Hippo-YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass

Assessment of Aspartate and Bicarbonate Produced From Hyperpolarized [1-13C]Pyruvate as Markers of Renal Gluconeogenesis

Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

The DEAD-box RNA helicase CshA is required for fatty acid homeostasis inStaphylococcus aureus

Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease

Novel Molecular Probes for Non-invasive Optical Imaging of Fatty Acid and Triglyceride Uptake in Living Animals

Structural basis for regulation of human acetyl-CoA carboxylase

Transforming Growth Factor beta/Activin signaling in neurons increases susceptibility to starvation

PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

Evidence for a neuromuscular circuit involving hypothalamic interleukin-6 in the control of skeletal muscle metabolism