Publications associées à Discovery and development of proton pump inhibitors

De novo designed proteins: a study in engineering novel folds and functions

Proteins control nearly every facet of life on a molecular level. Proteins are formed from linear strings of amino acids, which fold into three-dimensional structures that can enact functions. Evolution has created highly efficient proteins in diverse fold ...

EPFL2023

Computational design of novel protein–protein interactions – An overview on methodological approaches and applications

Bruno Emanuel Ferreira De Sousa Correia, Anthony Marchand, Alexandra Krina Van Hall-Beauvais

Protein–protein interactions (PPIs) govern numerous cellular functions in terms of signaling, transport, defense and many others. Designing novel PPIs poses a fundamental challenge to our understanding of molecular interactions. The capability to robustly ...

2022

Conditional essentiality of a complex I-like enzyme in strict anaerobes: the case of Desulfitobacterium

Christof Holliger, Julien Maillard, Romain Hamelin, Mathilde Stéphanie Willemin, Florence Armand

Respiratory complex I is a well-known player in aerobic respiration; it couples the transfer of two electrons from NADH to ubiquinone alongside with proton pumping. Bacterial complex I is usually composed of fourteen subunits forming three different module ...

2021

Breaking the Fourth Wall: Modulating Quaternary Associations for Protein Regulation and Drug Discovery

Yimon Aye, Bokyoung Kim

Protein-protein interactions (PPIs) are an effective means to orchestrate intricate biological processes required to sustain life. Approximately 650000 PPIs underlie the human interactome; thus underscoring its complexity and the manifold signaling outputs ...

WILEY-V C H VERLAG GMBH2019

Involvement of respiratory complex I in organohalide respiration?

Christof Holliger, Julien Maillard, Mathilde Stéphanie Willemin

Abstract Background The NADH:ubiquinone oxidoreductase (Nuo) is an assembly of proteins also known as complex I. It is the entry point for highly energetic electrons in the classical aerobic respiration process as it couples the transfer of two electrons f ...

2019

Intricacies of Cation-Anion Combinations in Imidazolium Salt-Catalyzed Cycloaddition of CO2 Into Epoxides

Paul Joseph Dyson, Gabor Laurenczy, Felix Daniel Bobbink, Florent Menoud, Martin Hulla, Dmitry Vasilyev, Sami Manoubi Armand Chamam

The cycloaddition of CO2 into epoxides catalyzed by imidazolium and related salts continues to attract attention due to the industrial importance of the cyclic carbonate products. The mechanism of the imidazolium-catalyzed transformation has been proposed ...

2018

Identifying the role of complex I in organohalide respiration of Firmicutes

Christof Holliger, Julien Maillard, Romain Hamelin, Mathilde Stéphanie Willemin

Organohalide-respiring bacteria (OHRB) are capable to link energy conservation with the use of organohalide compounds as terminal electron acceptors. While obligate OHRB relies only on this process for growing, facultative OHRB are able to use alternative ...

2018

Dual-pump generation of high-coherence primary Kerr combs with multiple sub-lines

Tobias Kippenberg, Maxim Karpov, Martin Hubert Peter Pfeiffer, Arne Kordts, Yan Yan, Long Li, Lin Zhang, Amirhossein Mohajerin Ariaei

We experimentally generate high-coherence primary Kerr combs with multiple sub-lines by using dual pumps and demonstrate the application of a primary comb state in multichannel communications. We find that more than 10 primary comb lines can be generated w ...

Optical Society of America2017

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Discovery and development of proton pump inhibitors

De novo designed proteins: a study in engineering novel folds and functions

Effects of thermal, mechanical, and electrostatic perturbations on lipid membrane hydration investigated by second harmonic imaging

Computational design of novel protein–protein interactions – An overview on methodological approaches and applications

Conditional essentiality of a complex I-like enzyme in strict anaerobes: the case of Desulfitobacterium

Developing the Catalytic Applications of 1,3,2-Diazaphospholenes

Breaking the Fourth Wall: Modulating Quaternary Associations for Protein Regulation and Drug Discovery

Involvement of respiratory complex I in organohalide respiration?

Intricacies of Cation-Anion Combinations in Imidazolium Salt-Catalyzed Cycloaddition of CO2 Into Epoxides

Identifying the role of complex I in organohalide respiration of Firmicutes

Dual-pump generation of high-coherence primary Kerr combs with multiple sub-lines

Graph Chatbot

Chattez avec Graph Search

Identifying the role of complex I in organohalide respiration of Firmicutes

Conditional essentiality of a complex I-like enzyme in strict anaerobes: the case of Desulfitobacterium

Developing the Catalytic Applications of 1,3,2-Diazaphospholenes

Effects of thermal, mechanical, and electrostatic perturbations on lipid membrane hydration investigated by second harmonic imaging

De novo designed proteins: a study in engineering novel folds and functions

Computational design of novel protein–protein interactions – An overview on methodological approaches and applications

Breaking the Fourth Wall: Modulating Quaternary Associations for Protein Regulation and Drug Discovery

Involvement of respiratory complex I in organohalide respiration?

Dual-pump generation of high-coherence primary Kerr combs with multiple sub-lines

Intricacies of Cation-Anion Combinations in Imidazolium Salt-Catalyzed Cycloaddition of CO2 Into Epoxides