Concept

Apomorphine

Publications associées (10)

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by alpha-synuclein overexpression

Grégoire Courtine, Laetitia Danielle Philippine Baud, Isabel Laura Vollenweider

Introduction: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons as well as the presence of proteinaceous inclusions named Lewy bodies. alpha synuclein (alpha-syn) is a major constituent o ...

Biomed Central Ltd2015

Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease

Patrick Aebischer, Bernard Schneider, Jean-Charles Bensadoun, Julien Dusonchet

Loss of function of parkin, an ubiquitin ligase, is responsible for autosomal recessive juvenile parkinsonism (AR-JP). Parkin-associated endothelin receptor-like receptor (Pael-R) was identified as an authentic substrate of parkin and is thought to accumul ...

2009

Apomorphine inhibitors of amyloid-beta (abeta) fibril formation and their use in amyloidosis based disease

Hilal Lashuel

Described is a new class of small molecule inhibitors of amyloid beta protein (Abeta) aggregation, based on apomorphine. These molecules target the nucleation phase of Abeta self-assembly and interfere effectively with aggregation of Abeta 1-40 into amyloi ...

2008

Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

Hilal Lashuel, Patrick Aebischer, Christophe Lo Bianco

Parkinson disease (PD) is characterized by dopaminergic neurodegeneration and intracellular inclusions of alpha-synuclein amyloid fibers, which are stable and difficult to dissolve. Whether inclusions are neuroprotective or pathological remains controversi ...

American Society for Clinical Investigation2008

Local GDNF expression mediated by lentiviral vector protects facial nerve motoneurons but not spinal motoneurons in SOD1(G93A) transgenic mice

Patrick Aebischer, Sandrine Guillot

Approximately 2% of amyotrophic lateral sclerosis (ALS) cases are associated with mutations in the cytosolic Cu/Zn superoxide dismutase 1 (SOD1) gene. Transgenic SOD1 mice constitute useful models of ALS to screen therapeutical approaches. Glial cell line- ...

2004

Apomorphine inhibitors of amyloid-beta (abeta) fibril formation and their use in amyloidosis based disease

Hilal Lashuel

2003

Chemical and physiological aspects of the actions of lithium and antidepressant drugs

Pierre Magistretti

The possible mechanisms underlying the anti-manic actions of lithium have been examined in a variety of interdisciplinary experiments. The possibility that lithium can regulate the sensitivity changes in dopaminergic transmission produced by chronic treatm ...

1983

Effects of chronic lithium treatment on dopamine receptors in the rat corpus striatum. I. Locomotor activity and behavioral supersensitivity

Pierre Magistretti

Spontaneous locomotor activity and dopaminergic responsivity were assessed after long-term dietary treatment with the anti-manic drug lithium. Chronic dietary Li administration was not accompanied by the toxicities often reported with other modes of admini ...

1982

Dopaminergic supersensitivity induced by denervation and chronic receptor blockade is additive

Pierre Magistretti

A persistent, severe reduction of synaptic transmission has been shown to enhance the responsiveness of postsynaptic tissue to the deficient neurotransmitter—a phenomenon called postjunctional supersensitivity. Regardless of whether supersensitivity is ind ...

1982

Potentiation of apomorphine-induced climbing behaviour in mice by d-LSD

Pierre Magistretti

The climbing behaviour in mice was used for studying possible interaction(s) of d-LSD with dopamine receptors. 2. Doses of d-LSD ranging from 0.25 to 2.5 mg/kg injected intra-peritoneally constantly inhibited the climbing behaviour. 3. In contrast, when ...

1979

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