Concept

Structural genomics

Publications associées (230)

Memory-error tolerance of Scalable and Highly Parallel Architecture for Restricted Boltzmann Machines in Deep Belief Network

Alexandre Schmid, Takao Marukame, Kodai Ueyoshi

A key aspect of constructing highly scalable Deep-learning microelectronic systems is to implement fault tolerance in the learning sequence. Error-injection analyses for memory is performed using a custom hardware model implementing parallelized restricted ...

Ieee2016

An operando emission spectroscopy study of Pt/Al2O3 and Pt/CeO2/Al2O3

Davide Ferri, Oliver Kröcher

In situ time-resolved spectroscopic examination of catalysts based on well dispersed nanoparticles on metal oxides under transient conditions significantly facilitates the elucidation of reaction mechanisms. In this contribution, we demonstrate the level o ...

Royal Soc Chemistry2016

Cryo-EM structure of aerolysin variants reveals a novel protein fold and the pore-formation process

Françoise Gisou van der Goot Grunberg, Matteo Dal Peraro, Mircea Ioan Iacovache, Nuria Cirauqui Diaz

Owing to their pathogenical role and unique ability to exist both as soluble proteins and transmembrane complexes, pore-forming toxins (PFTs) have been a focus of microbiologists and structural biologists for decades. PFTs are generally secreted as water-s ...

Nature Publishing Group2016

Branched Lateral Tail Fiber Organization in T5-Like Bacteriophages DT57C and DT571/2 is Revealed by Genetic and Functional Analysis

Ricardo Cesar Guerrero Ferreira, Nikolai Prokhorov

The T5-like siphoviruses DT57C and DT571/2, isolated from horse feces, are very closely related to each other, and most of their structural proteins are also nearly identical to T5 phage. Their LTFs (L-shaped tail fibers), however, are composed of two prot ...

Mdpi Ag2016

Catalytic Asymmetric Tandem Reaction of Tertiary Enamides: Expeditious Synthesis of Pyrrolo[2,1-a]isoquinoline Alkaloid Derivatives

Jieping Zhu

Reported is a new and efficient strategy for rapid construction of the chiral tetrahydropyrrolo[2,1-a]isoquinolin-3(2H)-one structure from unique tertiary enamide synthons. A Cu(OTf)2/chiral Pybox complex catalyzes the intramolecular enantioselective addit ...

Wiley-Blackwell2016

Learning from sparse codes

Pascal Frossard, Sofia Karygianni

In this paper we address the problem of learning image structures directly from sparse codes. We first model images as linear combinations of molecules, which are themselves groups of atoms from a redundant dictionary. We then formulate a new structure lea ...

Ieee2016

Structure elucidation of a complex CO2-based organic framework material by NMR crystallography

David Lyndon Emsley, Aaron James Rossini, Federico Maria Paruzzo

A three-dimensional structural model of a complex CO2-based organic framework made from high molecular weight, self-assembled, flexible and multi-functional oligomeric constituents has been determined de novo by solid-state NMR including DNP-enhanced exper ...

Royal Soc Chemistry2016

The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding

Pierre Gönczy, Georgios Hatzopoulos, Paul Guichard

Centrioles are microtubule-based structures that play important roles notably in cell division and cilium biogenesis. CEP135/Bld10p family members are evolutionarily conserved microtubule-binding proteins important for centriole formation. Here, we analyze ...

Elsevier2016

A geometrical approach to evaluate constitutive elements of structural robustness

Corentin Jean Dominique Fivet

The approach proposed here is linked to Maxwell’s reciprocal representation of force and geometry for structural modelling. It is based on the approach of Fivet & Zastavni [2014] of modelling interactive constraint-based structural equilibriums in which ge ...

2015

A geometrical approach to evaluating constitutive elements of structural robustness

Corentin Jean Dominique Fivet

2015

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