Concept
Syndrome lymphoprolifératif
Publications associées (8)
The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance
Johan Auwerx, Matthias Lütolf, Bart Deplancke, Carlos Canto Alvarez, Olaia Maria Naveiras Torres-Quiroga, George Coukos, Aurélien Laurent Jean-Charles Oggier, Loïc Tauzin, Dongryeol Ryu, Eija Riitta Pirinen, Pedro Romero, Vasco Ledebur de Antas de Campos, Mukul Girotra, Joanna Ratajczak, Josefine Catharina Pedersen Tratwal, Nicola Vannini, Pernille Yde Rainer, Gennady Nikitin, Federico Sizzano, Simone Ragusa, Vincent Trachsel, Sonja Giger, Shanti Rojas-Sutterlin, Yannick Lionel Yersin, Martin Ehrbar
It has been recently shown that increased oxidative phosphorylation, as reflected by increased mitochondrial activity, together with impairment of the mitochondrial stress response, can severely compromise hematopoietic stem cell (HSC) regeneration. Here w ...
CELL PRESS2019Microfluidics-assisted multiplexed biomarker detection for in situ mapping of immune cells in tumor sections
Martinus Gijs, Daniel Migliozzi, Diego Gabriel Dupouy, Benjamin Pelz
Because of the close interaction between tumors and the immune system, immunotherapies are nowadays considered as the most promising treatment against cancer. In order to define the diagnosis and the subsequent therapy, crucial information about the immune ...
2019Characterization of N-cadherin unbinding properties in non-malignant (HCV29) and malignant (T24) bladder cells
The expression of N-cadherin, characteristic of various cancers, very often leads to changes in the cells' adhesive properties. Thus, we sought to find out if N-cadherin expressed in various, but cancer-related cells, differs in its functional properties t ...
Wiley-Blackwell2011The Cell Differentiation Status Influences the Outcome of Notch-Induced Malignancy
The Notch signaling cascade is a well conserved pathway that regulates many aspects of embryonic development and plays a crucial role in the differentiation process and tissue homeostasis in multiple organs of adult species. Several human pathological diso ...
EPFL2011Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of notch signaling in the murine skin
Freddy Radtke, Ute Koch, Matteo Di Piazza
BACKGROUND: The Notch pathway is essential for proper epidermal differentiation during embryonic skin development. Moreover, skin specific loss of Notch signaling in the embryo results in skin barrier defects accompanied by a B-lymphoproliferative disease. ...
Public Library of Science2010Identification of genetic insulator elements to increase the safety of viral gene therapy vectors
Haematopoeitic system diseases, both acquired and inherited, can be currently cured by allogeneic haematopoietic stem cell transplantation. This treatment provides highly successful immune function recovery for patients receiving grafts of HLA-compatible d ...
EPFL2010Cofactor-based screening method for nuclear receptor modulators and related modulators
The invention relates to methods that enable identification of modulators of nuclear receptor (NR) activity and to methods for treating and/or preventing diseases or pathologic conditions associated with cell types that express said nuclear receptors. More ...
2003Modalities of interleukin-7-induced human immunodeficiency virus permissiveness in quiescent T lymphocytes
The metabolic and cell cycle status of primary T lymphocytes conditions their susceptibility to human immunodeficiency virus (HIV) and HIV-derived vectors. While in fully quiescent T lymphocytes the reverse transcription and nuclear import of these retroel ...
2002