Concept

Tétracycline

Publications associées (12)

Bactericidal effect of tetracycline in E. coli strain ED1a may be associated with ribosome dysfunction

Camille Véronique Bernadette Goemans, Christian Eugen Zimmerli, Martin Beck

Ribosomes translate the genetic code into proteins. Recent technical advances have facilitated in situ structural analyses of ribosome functional states inside eukaryotic cells and the minimal bacterium Mycoplasma. However, such analyses of Gram-negative b ...

2024

Bioaccumulation of antibiotics in wild freshwater invertebrates

Luiz Felippe De Alencastro, Marc Chevreuil

Occurrence and bioaccumulation of 20 antibiotics, including fluoroquinolones (FQs), sulfonamids (SAs), macrolids (MLs), tetracyclins (TCs),diaminopyrimidins (DPs) and nitro-imidazols (NIs) in an amphipod crustacean (Gammarus pulex) inhabiting in the small ...

2017

The microbiota provides colonisation resistance against intestinal helminths by regulating intestinal physiology

Luc Xavier Marie Lebon

Intestinal helminth infections are a global health problem affecting particularly people living in poor countries. Heavy worm burdens can lead to nutritional and cognitive deficiencies. Type-two immunity plays a crucial role in promoting tissue repair and ...

EPFL2017

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

Johan Auwerx, Bart Deplancke, Laurent Mouchiroud, Richardus Houtkooper, Dongryeol Ryu, Evan Graehl Williams, Xu Wang, Norman Lionel Moullan, Adrienne Joëlle Laurence Mottis, Virginija Jovaisaite, Michael Vincent Frochaux

In recent years, tetracyclines, such as doxycycline, have become broadly used to control gene expression by virtue of the Tet-on/Tet-off systems. However, the wide range of direct effects of tetracycline use has not been fully appreciated. We show here tha ...

Elsevier2015

Resistance to Diet-Induced Obesity and Associated Metabolic Perturbations in Haploinsufficient Monocarboxylate Transporter 1 Mice

Pierre Magistretti, Sylvain Eric Lengacher, Luc Pellerin

The monocarboxylate transporter 1 (MCT1 or SLC16A1) is a carrier of short-chain fatty acids, ketone bodies, and lactate in several tissues. Genetically modified C57BL/6J mice were produced by targeted disruption of the mct1 gene in order to understand the ...

Public Library of Science2013

Sources, Spreading and Fate of Antibiotic Resistance Genes and Resistant Bacteria in Vidy Bay, Lake Geneva, Switzerland

Nadine Czekalski

Increasing numbers of multiresistant bacterial pathogens cause severe health problems on a global scale. Large quantities of bacteria and their resistance genes are discharged into natural environments via human and animal waste. Not much is known so far a ...

EPFL2013

Laccases: Potential treatment for removal of micropollutants in municipal wastewater?

David Andrew Barry, Christof Holliger, Julien Maillard, Jonas Margot

Relatively high concentrations of micropollutants such as pharmaceuticals and biocides in municipal wastewater treatment plants (WWTP) effluents underscore the necessity to develop new treatments. Organisms that produce oxidative enzymes such as laccases a ...

2013

A Biochemical and Biophysical Investigation of 5-HT3 Receptor Stability

Menno Berend Tol

The 5-hydroxytryptamine 3 receptor (5-HT3R) is a member of the pentameric ligand-gated ion channel (pLGIC) family, that plays an important role in fast signal transduction and cell-cell communication in synapses: They convert a chemical signal from a neuro ...

EPFL2012

The role of aquatic reservoir fluctuations in long-term cholera patterns

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Lorenzo Righetto, Marino Gatto

We propose and analyze an important extension of standard cholera epidemiological models, explicitly accounting for fluctuations of water availability to the human community under study. The seasonality of water input in the reservoir drives the variation ...

2012

Influence of physical factors and geochemical conditions on groundwater acidification during enhanced reductive dechlorination

David Andrew Barry, Alessandro Brovelli, Clare Robinson

Enhanced reductive dehalogenation is an attractive in-situ treatment technology for chlorinated contaminants. The process includes two acid-forming microbial reactions, that is, fermentation of an organic substrate to hydrogen and short chain fatty acids f ...

2010

Graph Chatbot

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Connectez-vous pour utiliser Chat avec Graph Search