Concept

Cellule mésenchymateuse

Publications associées (426)

Mechanical and Functional Study of Cell Physiology at the Nanoscale

By live-cell imaging of biological samples dynamic cellular processes can be resolved. Fluorescence microscopy (FM) and atomic force microscopy (AFM) are both capable of imaging live cells. By combining these techniques structural as well as functional inf ...

EPFL2016

Tunable and cell-responsive 3D poly(ethylene glycol) microenvironments for the development of tissue models

Stéphanie Elisabeth Metzger

The recapitulation of tissue organization and function in vitro is one of the main objectives of tissue engineering. Proper tissue function depends on the spatial assembly and interactions between key components such as cells, growth factors, signaling cue ...

EPFL2016

Non-integrating episomal plasmid-based reprogramming of human amniotic fluid stem cells into induced pluripotent stem cells in chemically defined conditions

Lilia Salimova

Amniotic fluid stem cells (AFSC) represent an attractive potential cell source for fetal and pediatric cell-based therapies. However, upgrading them to pluripotency confers refractoriness toward senescence, higher proliferation rate and unlimited different ...

Taylor & Francis Inc2016

Human Hepatocyte-Derived Induced Pluripotent Stem Cells: MYC Expression, Similarities to Human Germ Cell Tumors, and Safety Issues

Marc Samuel Friedli, Carmen Maria Unzu Ezquerro

Induced pluripotent stem cells (iPSC) are a most promising approach to the development of a hepatocyte transplantable mass sufficient to induce long-term correction of inherited liver metabolic diseases, thus avoiding liver transplantation. Their intrinsic ...

2016

In vivo mechanical loading combined with cell therapy in a bone tissue engineering scaffold

Tanja Cloé Hausherr

Bone defects generate a worldwide high demand for bone repair and reconstruction. The incidence of bone defect repair in our aging society is expected to increase in the next decades. As bone auto- and allografting solutions often suffer from limited suppl ...

EPFL2016

GreA and GreB Enhance Expression of Escherichia coil RNA Polymerase Promoters in a Reconstituted Transcription-Translation System

Sebastian Maerkl, Zoe Newell Swank, Henrike Marie Niederholtmeyer

Cell-free environments are becoming viable alternatives for implementing biological networks in synthetic biology. The reconstituted cell-free expression system (PURE) allows characterization of genetic networks under defined conditions but its applicabili ...

Amer Chemical Soc2016

Fixation and Permeabilization Approaches for Scanning Electrochemical Microscopy of Living Cells

Hubert Girault, Horst Pick, Andreas Stephan Lesch, Fernando Cortes Salazar, Tzu-En Lin, Alexandra Bondarenko, Petar Stupar

Scanning electrochemical microscopy (SECM) has been widely used for the electrochemical imaging of dynamic topographical and metabolic changes in alive adherent mammalian cells. However, extracting intracellular information by SECM is challenging, since it ...

American Chemical Society2016

Substrate elasticity modulates the responsiveness of mesenchymal stem cells to commitment cues

Matthias Lütolf, Samy Gobaa

Fate choices of stem cells are regulated in response to a complex array of biochemical and physical signals from their microenvironmental niche. Whereas the molecular composition and the role of mechanical niche cues have been extensively studied, relative ...

Royal Soc Chemistry2015

Microencapsulated human mesenchymal stem cells decrease liver fibrosis in mice

Jutta Christine Wandrey, Redouan Mahou, Yannick Müller

Background & Aims: Mesenchymal stem cell (MSC) transplantation was shown to be effective for the treatment of liver fibrosis, but the mechanisms of action are not yet fully understood. We transplanted encapsulated human MSCs in two mouse models of liver fi ...

Elsevier Science Bv2015

Bioengineering approaches to emulate the stem cell niche

Sylke Höhnel

Stem cell therapies hold tremendous potential for tissue and organ regeneration. Yet, there remains significant need for better ex vivo culture and manipulation methods. On the one hand, many tissue-specific stem cells cannot be propagated without causing ...

EPFL2015

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