Publications associées à Conserved non-coding sequence

Evolutionally dynamic L1 regulation in embryonic stem cells

Didier Trono, Priscilla Turelli, Julien Léonard Duc, Marc Samuel Friedli, Adamantia Kapopoulou, Gabriela Ecco, Andrea Coluccio, Suk Min Jang

Mobile elements are important evolutionary forces that challenge genomic integrity. Long interspersed element-1 (L1, also known as LINE-1) is the only autonomous transposon still active in the human genome. It displays an unusual pattern of evolution, with ...

Cold Spring Harbor Lab Press, Publications Dept2014

A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy

Didier Trono, Jiri Vanicek, Isabelle Barde, Sonia Verp, Sandra Eloise Kjeldsen, Adamantia Kapopoulou, Andrea Corsinotti, Ray Marcel Marin Florez, Benjamin Rauwel

During hematopoiesis, lineage- and stage-specific transcription factors work in concert with chromatin modifiers to direct the differentiation of all blood cells. Here, we explored the role of KRAB-containing zinc finger proteins (KRAB-ZFPs) and their cofa ...

Amer Assoc Advancement Science2013

A yeast one-hybrid and microfluidics-based pipeline to map mammalian gene regulatory networks

Bart Deplancke, Sebastian Martin Waszak, Sunil Kumar Raghav, Alina Isakova, Jovan Simicevic, Jean-Daniel Feuz, Antonina Iagovitina

The comprehensive mapping of gene promoters and enhancers has significantly improved our understanding of how the mammalian regulatory genome is organized. An important challenge is to elucidate how these regulatory elements contribute to gene expression b ...

Nature / European Molecular Biology Organization2013

Topology of mammalian developmental enhancers and their regulatory landscapes

Denis Duboule

How a complex animal can arise from a fertilized egg is one of the oldest and most fascinating questions of biology, the answer to which is encoded in the genome. Body shape and organ development, and their integration into a functional organism all depend ...

Nature Publishing Group2013

High-resolution transcriptome and genome-wide dynamics of RNA polymerase and NusA in Mycobacterium tuberculosis

Stewart Cole, Jacques Rougemont, Claudia Sala, Swapna Uplekar

To construct a regulatory map of the genome of the human pathogen, Mycobacterium tuberculosis, we applied two complementary high-resolution approaches: strand-specific RNA-seq, to survey the global transcriptome, and ChIP-seq, to monitor the genome-wide dy ...

Oxford University Press2013

Genomic context analysis reveals dense interaction network between vertebrate ultraconserved non-coding elements

Philipp Bucher, Slavica Dimitrieva Janeva

Motivation: Genomic context analysis, also known as phylogenetic profiling, is widely used to infer functional interactions between proteins but rarely applied to non-coding cis-regulatory DNA elements. We were wondering whether this approach could provide ...

Oxford University Press2012

Chromosome Conformation Capture Uncovers Potential Genome-Wide Interactions between Human Conserved Non-Coding Sequences

Didier Trono, Isabelle Barde, Sonia Verp, Marc Samuel Friedli

Comparative analyses of various mammalian genomes have identified numerous conserved non-coding (CNC) DNA elements that display striking conservation among species, suggesting that they have maintained specific functions throughout evolution. CNC function ...

Public Library of Science2011

Dynamic control of endogenous retroviruses during development

Didier Trono, Helen Mary Rowe

Close to half of the human genome encompasses mobile genetic elements, most of which are retrotransposons. These genetic invaders are formidable evolutionary forces that have shaped the architecture of the genomes of higher organisms, with some conserving ...

Elsevier2011

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Conserved non-coding sequence

Evolutionally dynamic L1 regulation in embryonic stem cells

Computational analysis of ultraconserved non-coding DNA elements in vertebrate genomes

A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy

A yeast one-hybrid and microfluidics-based pipeline to map mammalian gene regulatory networks

Topology of mammalian developmental enhancers and their regulatory landscapes

High-resolution transcriptome and genome-wide dynamics of RNA polymerase and NusA in Mycobacterium tuberculosis

Highly Specific Methods for the Prediction of Genes Regulated by MicroRNAs

Genomic context analysis reveals dense interaction network between vertebrate ultraconserved non-coding elements

Chromosome Conformation Capture Uncovers Potential Genome-Wide Interactions between Human Conserved Non-Coding Sequences

Dynamic control of endogenous retroviruses during development

Graph Chatbot

Chattez avec Graph Search

A yeast one-hybrid and microfluidics-based pipeline to map mammalian gene regulatory networks

Evolutionally dynamic L1 regulation in embryonic stem cells

Computational analysis of ultraconserved non-coding DNA elements in vertebrate genomes

High-resolution transcriptome and genome-wide dynamics of RNA polymerase and NusA in Mycobacterium tuberculosis

A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy

Topology of mammalian developmental enhancers and their regulatory landscapes

Highly Specific Methods for the Prediction of Genes Regulated by MicroRNAs

Genomic context analysis reveals dense interaction network between vertebrate ultraconserved non-coding elements

Dynamic control of endogenous retroviruses during development

Chromosome Conformation Capture Uncovers Potential Genome-Wide Interactions between Human Conserved Non-Coding Sequences