Concept
Glande mammaire
Publications associées (54)
TGF beta-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression
Cathrin Brisken, Andrea Agnoletto
Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Virtually all women with DCIS are treated, despite evidence suggesting up to half would remain with stable, non-threatening, disease. Overtreatment thus presents a press ...
NATURE PORTFOLIO2023Estrogen receptor signaling in the human breast epithelium
Breast cancer is the most diagnosed malignancy in women worldwide, making effective prevention strategies crucial. Hormonal contraceptives, consisting of a synthetic progesterone receptor agonist alone or in combination with an estrogen, are used by millio ...
EPFL2022Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1
Cathrin Brisken, Giovanna Ambrosini, Georgios Sflomos, Ayyakkannu Ayyanan, Laura Battista, Philipp Bucher, Maryse Fiche, Valentina Scabia, Patrik Aouad, Fabio De Martino
Invasive lobular carcinoma (ILC) is the most frequent special histological subtype of breast cancer, typically characterized by loss of E‐cadherin. It has clinical features distinct from other estrogen receptor‐positive (ER+) breast cancers but the molecul ...
2021Membrane expression of the estrogen receptor ER alpha is required for intercellular communications in the mammary epithelium
Cathrin Brisken, Stéphanie Cagnet
17 beta-Estradiol induces the postnatal development of mammary gland and influences breast carcinogenesis by binding to the estrogen receptor ER alpha. ER alpha acts as a transcription factor but also elicits rapid signaling through a fraction of ER alpha ...
COMPANY BIOLOGISTS LTD2020The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche
Cathrin Brisken, Giovanna Ambrosini, Marian Caikovski, Philipp Bucher, Renuga Devi Rajaram, Patrik Aouad, Dalya Ataca, Marie Shamseddin, Céline Berthe Constantin, Csaba Ferenc László
Estrogens and progesterone control breast development and carcinogenesis via their cognate receptors expressed in a subset of luminal cells in the mammary epithelium. How they control the extracellular matrix, important to breast physiology and tumorigenes ...
202090 YEARS OF PROGESTERONE Progesterone receptor signaling in the normal breast and its implications for cancer
Cathrin Brisken, Valentina Scabia
Progesterone is considered as the pregnancy hormone and acts on many different target tissues. Progesterone receptor (PR) signaling is important for normal development and the physiologic function of the breast and impinges on breast carcinogenesis. Both s ...
BIOSCIENTIFICA LTD2020Adamts18 Function in Mammary Gland Development
Ovarian hormones control mammary gland development and impinge on breast carcinogenesis acting via their cognate receptors in the luminal epithelium. The extracellular matrix has a key role in physiology and disease but how the two are linked is poorly und ...
EPFL2019In vivo reprogramming of non-mammary cells to an epithelial cell fate is independent of amphiregulin signaling
Cathrin Brisken, Stéphanie Cagnet
AREG-/- mice demonstrate impaired mammary development and form only rudimentary ductal epithelial trees, however, AREG-/- glands are still capable of undergoing alveologenesis and lactogenesis during pregnancy. Transplantation of AREG-/- mammary epithelial ...
Company of Biologists2017