Concept
Chemotherapy regimen
Publications associées (23)
Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy caused by acquisition of genetic alterations during T-cell development. The 5-year overall survival of pediatric T-ALL patients has improved considerably over the past 30 ...
EPFL2023Hyperthermic intrathoracic chemotherapy to control malignant pleural mesothelioma
OBJECTIVE: Malignant pleural mesothelioma (MPM) is a rare disease that has a poor response to conventional therapy. Hyperthermic intrathoracic chemotherapy (HITOC), a treatment combining fever-range hyperthermia with intrapleural cisplatin chemotherapy, ha ...
EPFL2023Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation
Solid cancers exhibit a dynamic balance between cell death and proliferation ensuring continuous tumour maintenance and growth(1,2). Increasing evidence links enhanced cancer cell apoptosis to paracrine activation of cells in the tumour microenvironment in ...
NATURE PORTFOLIO2022Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice
Matthias Lütolf, Michele De Palma, Alan Nicolas Thierry Guichard, Mauro Delorenzi, Mario Leonardo Squadrito, Sina Nassiri, Nikolche Gjorevski, Simone Ragusa, Borja Prat Luri, Laureline Wetterwald
Mutations in APC promote colorectal cancer (CRC) progression through uncontrolled WNT signaling. Patients with desmoplastic CRC have a significantly worse prognosis and do not benefit from chemotherapy, but the mechanisms underlying the differential respon ...
2020Lymphoma Chemotherapy: Hungry Macrophages Strike the Final Blow
Macrophages modulate tumor response to chemotherapy; in this issue, Lossos and colleagues show that high-dose alkylating agents instigate a synthetic lethal program in lymphoma cells that is independent of DNA damage and involves recruitment and priming of ...
AMER ASSOC CANCER RESEARCH2019Carboplatin/paclitaxel, E7-vaccination and intravaginal CpG as tri-therapy towards efficient regression of genital HPV16 tumors
Douglas Hanahan, Gabriele Galliverti
High-risk human papillomavirus (HPV) are responsible for genital and oral cancers associated with the expression of the E6/E7 HPV oncogenes. Therapeutic vaccines targeting those oncogenes can only partially control tumor progression, highlighting the neces ...
BMC2019Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer
Mauro Delorenzi, Yu-Ting Huang
Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER-) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due ...
Springer2019RasGRP1 is a potential biomarker for stratifying anti-EGFR therapy response in colorectal cancer
Mauro Delorenzi, Delphine Yvette L Grun
Colorectal cancer (CRC) is the third most frequent neoplastic disorder and is a main cause of tumor-related mortality, as many patients progress to stage IV metastatic CRC. Standard care consists of combination chemotherapy (FOLFIRI or FOLFOX). Patients wi ...
AMER SOC CLINICAL INVESTIGATION INC2019Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models
Michele De Palma, Alan Nicolas Thierry Guichard, Mario Leonardo Squadrito, Chiara Cianciaruso, Esra Güç, Ioanna Keklikoglou, Antonino Cassarà
Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However, experimental studies in mice also suggest that chemotherapy has pro-metastatic effects. Primary tumours release extracellular vesicles (EVs), including exosomes, that can ...
2019Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis
Paul Joseph Dyson, Gerardo Turcatti, Fabien Kuttler, Damiano Banfi, Hristo Plamenov Varbanov
Drug combinations are extensively used to treat cancer and are often selected according to complementary mechanisms. Here, we describe a cell-based high-throughput screening assay for identification of synergistic combinations between broadly applied plati ...
2019