Concept

Hyperprolactinémie

Publications associées (13)

Schizophrenia patients using atypical medication perform better in visual tasks than patients using typical medication

Schizophrenia (SCZ) patients show deficits in many domains, including cognition and perception. However, results are often mixed. One reason for mixed results may be differences in medication. Very little is known about the role of medication in visual pro ...

2019

Dopamine induces soluble alpha-synuclein oligomers and nigrostriatal degeneration

Elpida Tsika

Parkinson's disease (PD) is defined by the loss of dopaminergic neurons in the substantia nigra and the formation of Lewy body inclusions containing aggregated alpha-synuclein. Efforts to explain dopamine neuron vulnerability are hindered by the lack of do ...

Nature Publishing Group2017

Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast

Cathrin Brisken, Georgios Sflomos, Ayyakkannu Ayyanan, Maryse Fiche, Tamara Tanos, Maria Gutierrez Najera

Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. Receptor activator of nuclear factor ...

American Association for the Advancement of Science2013

Functional consequences of prolactin signaling in endothelial cells: a potential link with angiogenesis in pathophysiology?

Patrycja Nowak-Sliwinska

Prolactin is best known as the polypeptide anterior pituitary hormone, which regulates the development of the mammary gland. However, it became clear over the last decade that prolactin contributes to a broad range of pathologies, including breast cancer. ...

2012

Role of canonical Wnt signaling in mammary gland development

Renuga Devi Rajaram

The female reproductive hormones estrogens, progesterone, and prolactin control postnatal breast development and are important to breast carcinogenesis. In particular, exposure to progesterone is tightly linked to breast cancer risk. Using the mouse as a m ...

EPFL2010

Protein-Resistant Surfaces through Mild Dopamine Surface Functionalization

Karl Gademann, Simone Bonazzi, Jean-Yves Wach

The synthesis and evaluation of new dopamine-based catechol anchors coupled to poly(ethylene glycol) (PEG) for surface modification of TiO2 are reported. Dopamine is modified by dimethylamine-methylene or trimethylammonium- methylene groups, and the prepar ...

2008

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation

PTEN acts as a tumor suppressor in a range of tissue types and has been implicated in the regulation of intestinal stem cells. To study Pten function in the intestine, we used various conditional transgenic strategies to specifically delete Pten from the m ...

2008

Using gene expression arrays to elucidate transcriptional profiles underlying prolactin function

Cathrin Brisken

Prolactin is an ancient hormone, with different functions in many species. The binding of prolactin to its receptor, a member of the cytokine receptor superfamily, results in the activation of different intracellular signaling pathways, such as JAK2/STAT5, ...

2003

IGF-2 is a mediator of prolactin-induced morphogenesis in the breast

Cathrin Brisken

The mechanisms by which prolactin controls proliferation of mammary epithelial cells (MECs) and morphogenesis of the breast epithelium are poorly understood. We show that cyclin D1(-/-) MECs fail to proliferate in response to prolactin and identify IGF-2 a ...

2002

Application of surface biopassivated disposable poly(dimenthylsiloxane)/glass chips to a heterogeneous competitive human serum immunoglobulin G immunoassy with incorporated internal standard

Nico de Rooij

A microfluidic platform for a heterogeneous competitive immunoassay of human immunoglobulin G (IgG) employing Cy5-human IgG as tracer and Cy3-mouse IgG as internal standard was developed. The device consisted of microchannels made of poly(dimethylsiloxane) ...

2002

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