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Plant natural products (PNPs) and their derivatives are important but underexplored sources of pharmaceutical molecules. To access this untapped potential, the reconstitution of heterologous PNP biosynthesis pathways in engineered microbes provides a valua ...
We study a variant of the interpolation problem where the continuously defined solution is regularized by minimizing the L-p-norm of its second-order derivative. For this continuous-domain problem, we propose an exact discretization scheme that restricts t ...
We compare the performance of the perturbation-based (local) portfolio solution method of Devereux & Sutherland (2010a, 2011) with a global solution method. As a test suite we use model specifications that broadly capture features of international financia ...
To date, no fringe analysis technique has the capability to provide simultaneous and direct estimation of the continuous distributions corresponding to the interference phase and its first and second-order derivatives within the framework of a single inter ...
We introduce a density-functional perturbational scheme based on ultrasoft pseudopotentials for calculating dielectric tensors of periodic systems. We obtain a variational functional for the second-order derivative of the energy with respect to an electric ...
We study a variant of the interpolation problem where the continuously defined solution is regularized by minimizing the L p -norm of its second-order derivative. For this continuous-domain problem, we propose an exact discretization scheme that restricts ...
We develop a novel 2D functional learning framework that employs a sparsity-promoting regularization based on second-order derivatives. Motivated by the nature of the regularizer, we restrict the search space to the span of piecewise-linear box splines shi ...
We introduce a novel family of invariant, convex, and non-quadratic functionals that we employ to derive regularized solutions of ill-posed linear inverse imaging problems. The proposed regularizers involve the Schatten norms of the Hessian matrix, which a ...