Concept

Bone resorption

Publications associées (51)

Surgical preparation of bone-scaffold interface is critical for bone regeneration inside tissue engineering scaffold

Dominique Pioletti, Alireza Roshan Ghias

The goal of this study was to investigate if the preparation of implantation site has an impact on bone formation inside tissue engineering scaffolds. For this purpose, two different drilling techniques were used to create a hole in distal femurs of rats b ...

Wiley-Blackwell2011

Proximal tibia volumetric bone mineral density is correlated to the magnitude of local acceleration in male long distance runners

Kamiar Aminian, Bijan Najafi

Deriaz O, Najafi B, Ballabeni P, Crettenand A, Gobelet C, Aminian K, Rizzoli R, Gremion G. Proximal tibia volumetric bone mineral density is correlated to the magnitude of local acceleration in male long-distance runners. J Appl Physiol 108: 852-857, 2010. ...

2010

mu-PIXE and SAXS studies at the bone-cartilage interface

Micro Proton Induced X-ray Emission (mu-PIXE) analysis has been employed herein in investigating and quantifying the distribution of a number of essential elements in thin human diseased articular cartilage sections affected by osteoarthritis (OA). Various ...

2010

In vivo cyclic loading as a potent stimulatory signal for bone formation inside tissue engineering scaffolds

Dominique Pioletti, Alexandre Terrier, Pierre-Etienne Bourban, Alireza Roshan Ghias

In clinical situations, bone defects are often located at load bearing sites. Tissue engineering scaffolds are future bone substitutes and hence they will be subjected to mechanical stimulation. The goal of this study was to test if cyclic loading can be u ...

European Cells & Materials Ltd2010

Prediction and optimization of bone density around orthopedic implants delivering bisphosphonate

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

The fixation of an orthopedic implant depends strongly upon its initial stability. Peri-implant bone may resorb shortly after the surgery. This resorption is directly followed by new bone formation and implants fixation strengthening, the so-called seconda ...

2009

3D model of bone remodeling coupled with a drug effect

Philippe Abdel Sayed

Total hip replacement, which is a successful solution for restoring movement to damaged joints, becomes nowadays a common surgical procedure. However the lifespan of hip implants is limited, because of pathologic strain distribution in bone inducing bone-r ...

2009

Osteoclastogenesis can be mechanically-induced in the peri-implant bone

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

Total joint replacements are highly successful in relieving pain and restoring movement of damaged joints. However, the lifespan of the implants is limited. The implant’s long-term stability depends largely on the preservation of periprosthetic bone. Debri ...

2009

The role of MYC in bone and in the hematopoietic stem cell niche

Maike Jaworski

The nuclear protein c-Myc is one of the most potent proto-oncogenes described. Its expression is found to be deregulated in more than 50 percent of human cancers, where it has been shown to control a number of biological processes including driving prolife ...

EPFL2009

3D strain map of axially loaded mouse tibia: a numerical analysis validated by experimental measurements

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann, Francesco Merlini, Vincent Forster, Jean Hocké

A combined experimental/numerical study was performed to calculate the zone of highest strain in a rat tibia loaded axially. This study is motivated by the fact that the bone remodeling analysis in this in vivo rat model should be performed at the zone of ...

2009

3D strain map of axially loaded mouse tibia: a numerical analysis validated by experimental measurements

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann, Francesco Merlini, Vincent Forster, Jean Hocké, Jensen Verhelle

A combined experimental/numerical study was performed to calculate the 3D octahedral shear strain map in a mouse tibia loaded axially. This study is motivated by the fact that the bone remodelling analysis, in this in vivo mouse model should be performed a ...

2009

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