Publications associées à ARN polymérase III

Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase

Stewart Cole, Claudia Sala, Wareed Ahmed

Movement of the transcription machinery along a template alters DNA topology resulting in the accumulation of supercoils in DNA. The positive supercoils generated ahead of transcribing RNA polymerase (RNAP) and the negative supercoils accumulating behind i ...

Public Library Science2017

Transcriptional regulatory logic of the diurnal cycle in the mouse liver

Matteo Dal Peraro, Bart Deplancke, Felix Naef, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger, Sunil Kumar Raghav, Nouria Hernandez, Irina Krier, Guillaume Rey, Alexandra Styliani Kalantzi, Jonathan Aryeh Sobel

Many organisms exhibit temporal rhythms in gene expression that propel diurnal cycles in physiology. In the liver of mammals, these rhythms are controlled by transcription-translation feedback loops of the core circadian clock and by feeding-fasting cycles ...

Public Library of Science2017

Influence of Rotational Nucleosome Positioning on Transcription Start Site Selection in Animal Promoters

Giovanna Ambrosini, Philipp Bucher, René Dreos

The recruitment of RNA-Pol-II to the transcription start site (TSS) is an important step in gene regulation in all organisms. Core promoter elements (CPE) are conserved sequence motifs that guide Pol-II to the TSS by interacting with specific transcription ...

Public Library Science2016

Single Molecule Localization and Discrimination of DNA–Protein Complexes by Controlled Translocation Through Nanocapillaries

Aleksandra Radenovic, Sebastian Maerkl, Sanjin Marion, Roman Bulushev, Sebastian James Davis, Ekaterina Emilova Petrova

Through the use of optical tweezers we performed controlled translocations of DNA-protein complexes through nanocapillaries. We used RNA polymerase (RNAP) with two binding sites on a 7.2 kbp DNA fragment and a dCas9 protein tailored to have five binding si ...

American Chemical Society2016

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance

Johan Auwerx, Norman Lionel Moullan, Nouria Hernandez, Gilles Willemin, Rajat Singh

MAF1 is a global repressor of RNA polymerase III transcription that regulates the expression of highly abundant noncoding RNAs in response to nutrient availability and cellular stress. Thus, MAF1 function is thought to be important for metabolic economy. H ...

Cold Spring Harbor Lab Press, Publications Dept2015

Detection of Convergent Genome-Wide Signals of Adaptation to Tropical Forests in Humans

Matthieu Foll

Tropical forests are believed to be very harsh environments for human life. It is unclear whether human beings would have ever subsisted in those environments without external resources. It is therefore possible that humans have developed recent biological ...

Public Library of Science2015

Upstream Binding of Idling RNA Polymerase Modulates Transcription Initiation from a Nearby Promoter

Giovanni Dietler, Aleksandre Japaridze

The bacterial gene regulatory regions often demonstrate distinctly organized arrays of RNA polymerase binding sites of illdefined function. Previously we observed a module of closely spaced polymerase binding sites upstream of the canonical promoter of the ...

American Society for Biochemistry and Molecular Biology2015

A large-scale, in vivo transcription factor screen defines bivalent chromatin as a key property of regulatory factors mediating Drosophila wing development

Bart Deplancke, Monica Albarca Aguilera

Transcription factors (TFs) are key regulators of cell fate. The estimated 755 genes that encode DNA binding domain-containing proteins comprise similar to 5% of all Drosophila genes. However, the majority has remained uncharacterized so far due to the lac ...

Cold Spring Harbor Laboratory Press2015

Population Variation and Genetic Control of Modular Chromatin Architecture in Humans

Bart Deplancke, David Hacker, Sebastian Martin Waszak, Sunil Kumar Raghav, Nouria Hernandez, Gilles Udin, Alisa Yurovsky, Sarah Thurnheer

Chromatin state variation at gene regulatory elements is abundant across individuals, yet we understand little about the genetic basis of this variability. Here, we profiled several histone modifications, the transcription factor (TF) PU.1, RNA polymerase ...

Elsevier2015

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ARN polymérase III

Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase

Transcriptional regulatory logic of the diurnal cycle in the mouse liver

Phase specific transcriptional regulation of circadian clock and metabolism in mouse liver

Influence of Rotational Nucleosome Positioning on Transcription Start Site Selection in Animal Promoters

Single Molecule Localization and Discrimination of DNA–Protein Complexes by Controlled Translocation Through Nanocapillaries

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance

Detection of Convergent Genome-Wide Signals of Adaptation to Tropical Forests in Humans

Upstream Binding of Idling RNA Polymerase Modulates Transcription Initiation from a Nearby Promoter

A large-scale, in vivo transcription factor screen defines bivalent chromatin as a key property of regulatory factors mediating Drosophila wing development

Population Variation and Genetic Control of Modular Chromatin Architecture in Humans

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Chattez avec Graph Search

A large-scale, in vivo transcription factor screen defines bivalent chromatin as a key property of regulatory factors mediating Drosophila wing development

Transcriptional regulatory logic of the diurnal cycle in the mouse liver

Phase specific transcriptional regulation of circadian clock and metabolism in mouse liver

Single Molecule Localization and Discrimination of DNA–Protein Complexes by Controlled Translocation Through Nanocapillaries

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance

Detection of Convergent Genome-Wide Signals of Adaptation to Tropical Forests in Humans

Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase

Influence of Rotational Nucleosome Positioning on Transcription Start Site Selection in Animal Promoters

Upstream Binding of Idling RNA Polymerase Modulates Transcription Initiation from a Nearby Promoter

Population Variation and Genetic Control of Modular Chromatin Architecture in Humans