Concept

Glutathion réductase

Publications associées (46)

Dualities in plant tolerance to pollutants and their uptake and translocation to the upper plant parts

There is a duality in plant tolerance to pollutants and its response to the pollutants’ stress. On the one hand some plants, (hyper)tolerant to heavy metals, are able to hyperaccumulate these metals in shoots, which could be beneficial for phytoremediation ...

2009

Comparison of T-1 Relaxation Times of the Neurochemical Profile in Rat Brain at 9.4 Tesla and 14.1 Tesla

Rolf Gruetter, Lijing Xin, Cristina Ramona Cudalbu

Knowledge of T-1 relaxation times can be important for accurate relative and absolute quantification of brain metabolites, for sensitivity optimizations, for characterizing molecular dynamics, and for studying changes induced by various pathological condit ...

Wiley-Blackwell2009

Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs

Angela Casini

The thioredoxin system plays a key role in regulating the overall intracellular redox balance. It basically comprises the small redox protein thioredoxin (Trx), nicotinamide adenine dinucleotide phosphate, in its reduced form (NADPH), and thioredoxin reduc ...

2009

Stability of an organometallic ruthenium-ubiquitin adduct in the presence of glutathione: Relevance to antitumor activity

Paul Joseph Dyson, Yury Tsybin, Christian Hartinger, Angela Casini, Céline Rita Duhot

The interactions of the ruthenium(II) complex Ru(η6-p-cymene)(pta)Cl2 (RAPTA-C), an effective anticancer and antimetastatic agent, with biol. nucleophiles are important with respect to its mechanism of action, for example, the reaction with glutathione (GS ...

2008

Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium(II)-Arene Compounds

Paul Joseph Dyson, Christian Hartinger, Angela Casini

A series of ruthenium(II)-arene (RAPTA) compds. were evaluated for their ability to inhibit thioredoxin reductase (either cytosolic or mitochondrial) and cathepsin B, two possible targets for anticancer metallodrugs. In general, inhibition of the thioredox ...

2008

One-step refolding and purification of disulfide-containing proteins with a C-terminal MESNA thioester

Maartje Martina Cornelia Bastings

Background Expression systems based on self-cleavable intein domains allow the generation of recombinant proteins with a C-terminal thioester. This uniquely reactive C-terminus can be used in native chemical ligation reactions to introduce synthetic groups ...

BioMed Central2008

Neurochemical changes in Huntington R6/2 mouse striatum detected by in vivo 1H NMR spectroscopy

Rolf Gruetter

The neurochemical profile of the striatum of R6/2 Huntington's disease mice was examined at different stages of pathogenesis using in vivo1H NMR spectroscopy at 9.4 T. Between 8 and 12 weeks, R6/2 mice exhibited distinct changes in a set of 17 quantifiable ...

Wiley-Blackwell2007

Detection of an antioxidant profile in the human brain in vivo via double editing with MEGA-PRESS

Rolf Gruetter

Vitamin C (ascorbate) and glutathione (GSH) are the two most concentrated non-enzymatic antioxidants in the human brain. Double editing with (DEW) MEGA-PRESS at 4T was designed in this study to measure both antioxidants in the same amount of time previousl ...

Wiley-Blackwell2006

Lentivirus-mediated expression of glutathione peroxidase: neuroprotection in murine models of Parkinson's disease

Patrick Aebischer, Jean-Charles Bensadoun

Reactive oxygen species are considered to contribute to the pathogenesis of Parkinson's disease (PD). In order to study viral vector-mediated overexpression of the antioxidant enzyme glutathione peroxidase (GPX) as a potential neuroprotective approach in b ...

2006

Conjugation of atrazine in vetiver (Chrysopogon zizanioides Nash) grown in hydroponics

Jean-Paul Schwitzguebel, Sylvie Vullioud-Marcacci

The resistance mechanism of vetiver (Chrysopogon zizanioides Nash) to atrazine was investigated to evaluate its potential for phytoremediation of environment contaminated with the herbicide. Plants known to metabolise atrazine rely on hydroxylation mediate ...

Elsevier2006

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