Concept

HeLa

Publications associées (105)

Association of Helicobacter pylori vacuolating toxin (VacA) with lipid rafts

Yiming Li, Françoise Gisou van der Goot Grunberg

A variety of extracellular ligands and pathogens interact with raft domains in the plasma membrane of eukaryotic cells. In this study, we examined the role of lipid rafts and raft-associated glycosylphosphatidylinositol (GPI)-anchored proteins in the proce ...

2002

Synthesis of cyclo-β-tripeptides and their biological in vitro evaluation as antiproliferatives against the growth of human cancer cell lines

Karl Gademann

A number of cyclo-β-tripeptides and their linear precursors were subjected to primary biol. evaluation for cancer-cell growth inhibition (one-dose, three-cell essay), and the five most active ones were then tested in the anti-tumor screen of the National C ...

2001

In vitro binding of nucleolin to double-stranded telomeric DNA

Thierry Laroche

We have purified a 100 kDa protein, resolved in a Southwestern binding screen of total nuclear proteins from Hela cells with double-stranded human telomeric probe. A polyclonal antiserum raised by this protein recognizes purified nucleolin and stains nucle ...

2000

Molecular cloning and immunolocalization of a novel vertebrate trp homologue from Xenopus

Carl Petersen

We report the sequence, structure and distribution of a novel transient receptor potential (trp) homologue from Xenopus, Xtrp, determined by screening an oocyte cDNA library. On the basis of sequence similarity and predicted structure, Xtrp appears to be a ...

1999

Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes

Françoise Gisou van der Goot Grunberg

Brucella abortus is an intracellular pathogen that replicates within a membrane-bounded compartment. In this study, we have examined the intracellular pathway of the virulent B. abortus strain 2308 (S2308) and the attenuated strain 19 (S19) in HeLa cells. ...

1998

Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons

Daniel Constam

The puromycin-sensitive aminopeptidase (PSA) is thought to contribute to the degradation of enkephalins. Besides being the most abundant aminopeptidase in the brain, PSA is expressed in other organs as well. From a human fetal brain cDNA library, we have i ...

Wiley-Blackwell1997

Telomeric localization of TRF2, a novel human telobox protein

Thierry Laroche

Natural chromosomal ends are stabilized by proteins that bind duplex telomeric DNA repeats. In human cells, the TTAGGG Repeat Factor 1 (TRF1) was identified by two independent studies, one screening for factors that bind duplex telomeric DNA and the other ...

1997

The inability of cells to grow in low iron correlates with increasing activity of their iron regulatory protein (IRP)

Lukas Kühn

We studied the factors that determine the differing growth requirements of low-iron-tolerant (LIT) versus high-iron-dependent (HID) cells for extracellular nontransferrin iron. The growth of LIT cells HeLa and THP-1, when transferred from transferrin (5 mi ...

1997

Identification and characterization of novel promoters in the genome of human papillomavirus type 18

Peter Martin Beard

Most studies on the regulation of gene expression in human papillomaviruses (HPV) have focused on the promoter for the early genes E6 and E7. This promoter is located at the junction between the long control region and the E6 open reading frame. RNA mappin ...

1993

Herpes simplex virions interfere with the expression of human papillomavirus type 18 genes

Peter Martin Beard

Papillomaviruses are believed to play an important role in the development of genital carcinoma. Herpes simplex virus (HSV) has been proposed as a cofactor. Here we show that HSV-1 interferes with the expression of human papillomavirus (HPV-18) genes in He ...

1993

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