Concept

Gene polymorphism

Publications associées (99)

An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy

Jeffrey David Jensen, Matthieu Foll, Claudia Bank, Sebastian Matuszewski, Hyunjin Shim

The rapid evolution of drug resistance remains a critical public health concern. The treatment of influenza A virus (IAV) has proven particularly challenging, due to the ability of the virus to develop resistance against current antivirals and vaccines. He ...

Wiley-Blackwell2016

Alpha7 subunit of the nicotinergic acethylcholine receptor gene (CHRNA7) and perception of coherent motion in aging

Michael Herzog

Genetic variations of the alpha7 subunit of the nicotinergic acetylcholine receptor gene (CHRNA7) are linked to cognitive deficits in aging and schizophrenia. However, little is known about associations of the CHRNA7 gene with aged-related decline in visua ...

2016

Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans

Yunfei Huang

Objective: Plasma kynurenine/tryptophan ratio, a biomarker of indoleamine 2,3-dioxygenase-1 (IDO) activity, is a strong independent predictor of mortality in HIV-infected Ugandans initiating antiretroviral therapy (ART) and may play a key role in HIV patho ...

Lippincott Williams & Wilkins2016

A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance

Jeffrey David Jensen, Claudia Bank, Li Jiang

The therapeutic benefits of the neuraminidase (NA) inhibitor oseltamivir are dampened by the emergence of drug resistance mutations in influenza A virus (IAV). To investigate the mechanistic features that underlie resistance, we developed an approach to qu ...

Academic Press Ltd- Elsevier Science Ltd2016

Molecular Analysis of NOTCH2 in Patients with Primary Open-Angle Glaucoma

Background and Purpose: Transgenic mice over-expressing Notch2 in the uvea exhibit a hyperplastic ciliary body leading to increased IOP and glaucoma. The aim of this study was to investigate the possible presence of NOTCH2 variants in patients with primary ...

Georg Thieme Verlag Kg2015

Effects as Implicit Capabilities

Martin Odersky

We propose to investigate a new approach to effect checking that has an elegant solution to the effect polymorphism problem. The central idea is that instead of talking about effects we talk about capabilities. For instance, instead of saying a function “t ...

2015

The impact of host genetic variation on infection with HIV-1

The outcome after infection with the human immunodeficiency virus type 1 (HIV-1) is a complex phenotype determined by interactions among the pathogen, the human host and the surrounding environment. An impact of host genetic variation on HIV-1 susceptibili ...

Nature Publishing Group2015

Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols

Background Efavirenz and abacavir are components of recommended first-line regimens for HIV-1 infection. We used genome-wide genotyping and clinical data to explore genetic associations with virologic failure among patients randomized to efavirenz-containi ...

Lippincott Williams & Wilkins2015

Drosophila innate immunity: regional and functional specialization of prophenoloxidases

Bruno Lemaitre, Jan Paul Dudzic

The diversification of immune systems during evolution involves the expansion of particular gene families in given phyla. A better understanding of the metazoan immune system requires an analysis of the logic underlying such immune gene amplification. This ...

BioMed Central2015

Selection methods regulate evolution of cooperation in digital evolution

Dario Floreano, Laurent Keller, Pawel Lichocki

A key, yet often neglected, component of digital evolution and evolutionary models is the 'selection method' which assigns fitness (number of offspring) to individuals based on their performance scores (efficiency in performing tasks). Here, we study with ...

Royal Soc2014

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