Concept

Thyréostimuline

Publications associées (48)

Combining ion mobility spectrometry and cryogenic ion spectroscopy with enzymatic digestion/synthesis for the study of N-linked glycans

Glycans play an essential role in numerous physiological and pathological processes of living organisms. Despite their significant biological relevance, glycobiology remains one of the least explored fields of biochemistry. The intrinsic isomeric complexit ...

EPFL2023

Cryo-EM structure of native human thyroglobulin

Henning Paul-Julius Stahlberg

The thyroglobulin (TG) protein is essential to thyroid hormone synthesis, plays a vital role in the regulation of metabolism, development and growth and serves as intraglandular iodine storage. Its architecture is conserved among vertebrates. Synthesis of ...

2022

Non-genomic activation of the AKT-mTOR pathway by the mitochondrial stress response in thyroid cancer

Johan Auwerx, Kristina Schoonjans, Dongryeol Ryu

Cancer progression is associated with metabolic reprogramming and causes significant intracellular stress; however, the mechanisms that link cellular stress and growth signalling are not fully understood. Here, we identified a mechanism that couples the mi ...

SPRINGERNATURE2022

Extended gate field-effect-transistor for sensing cortisol stress hormone

Mihai Adrian Ionescu, Junrui Zhang, Sadegh Kamaei Bahmaei, Hoël Maxime Guérin, Luca Capua, Shokoofeh Sheibani, Sayedeh Shirin Afyouni Akbari

Cortisol is a hormone released in response to stress and is a major glucocorticoid produced by adrenal glands. Here, we report a wearable sensory electronic chip using label-free detection, based on a platinum/graphene aptamer extended gate field effect tr ...

SPRINGERNATURE2021

A Software Tool for the Real-Time in Vivo Evaluation of Neural Electrodes' Selectivity

Silvestro Micera, Stanisa Raspopovic, Francesco Maria Petrini, Ivo Strauss, Daniela De Luca

High neural selectivity is an important indicator of how well a neural electrode will perform in a clinical setup. Among other factors, neural selectivity of an electrode strongly depends on its implant location. Today, the neural selectivity is evaluated ...

IEEE2021

Spearheading future omics analyses using dyngen, a multi-modal simulator of single cells

Wouter Saelens

We present dyngen, a multi-modal simulation engine for studying dynamic cellular processes at single-cell resolution. dyngen is more flexible than current single-cell simulation engines, and allows better method development and benchmarking, thereby stimul ...

NATURE RESEARCH2021

Lactate enhancing compounds and uses thereof

Pierre Magistretti, Sylvain Eric Lengacher, Charles Léonard Finsterwald

Abstract of the invention: The present invention relates to new agents useful for stimulating release of lactate by astrocytes. The invention further relates to methods of preparation, formulations and therapeutic uses of those agents, notably for the prev ...

2020

Impact of iron- and/or sulfate-reduction on a cis-1,2-dichloroethene and vinyl chloride respiring bacterial consortium: experiments and model-based interpretation

Christof Holliger, Julien Maillard, Alexandra Marie Murray

Process understanding of microbial communities containing organohalide-respiring bacteria (OHRB) is important for effective bioremediation of chlorinated ethenes. The impact of iron and sulfate reduction on cis-1,2-dichloroethene (cDCE) and vinyl chloride ...

ROYAL SOC CHEMISTRY2020

A CMOS Image Sensor Pixel Combining Deep Sub-Electron Noise With Wide Dynamic Range

Christian Enz, Assim Boukhayma, Antonino Caizzone

This letter introduces a 5-transistors (5T) implementation of CMOS Image Sensors (CIS) pixels enabling the combination of deep sub-electronnoise performance with wide dynamic range (DR). The 5T pixel presents a new technique to reduce the sense node capaci ...

2020

Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell

Steinunn Baekkeskov Hanahan, Chiara Cianciaruso, Petra Catalina Schwalie, Edward Allen Phelps

Pancreatic beta cells synthesize and secrete the neurotransmitter GABA (gamma-aminobutyric acid) as a paracrine and autocrine signal to help regulate hormone secretion and islet homeostasis. Islet GABA release has classically been described as a secretory- ...

2019

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