Concept
Spatial cognition
Personnes associées (53)
Jean-Philippe Thiran
Jean-Philippe Thiran was born in Namur, Belgium, in August 1970. He received the Electrical Engineering degree and the PhD degree from the Université catholique de Louvain (UCL), Louvain-la-Neuve, Belgium, in 1993 and 1997, respectively. From 1993 to 1997, he was the co-ordinator of the medical image analysis group of the Communications and Remote Sensing Laboratory at UCL, mainly working on medical image analysis. Dr Jean-Philippe Thiran joined the Signal Processing Institute (ITS) of the Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland, in February 1998 as a senior lecturer. He was promoted to Assistant Professor in 2004, to Associate Professor in 2011 and is now a Full Professor since 2020. He also holds a 20% position at the Department of Radiology of the University of Lausanne (UNIL) and of the Lausanne University Hospital (CHUV) as Associate Professor ad personam. Dr Thiran's current scientific interests include
Computational medical imaging: acquisition, reconstruction and analysis of imaging data, with emphasis on regularized linear inverse problems (compressed sensing, convex optimization). Applications to medical imaging: diffusion MRI, ultrasound imaging, inverse planning in radiotherapy, etc.Computer vision & machine learning: image and video analysis, with application to facial expression recognition, eye tracking, lip reading, industrial inspection, medical image analysis, etc.
Henry Markram
Henry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Pierre Magistretti
Pierre J. Magistretti is an internationally-recognized neuroscientist who has made significant contributions in the field of brain energy metabolism. His group has discovered some of the cellular and molecular mechanisms that underlie the coupling between neuronal activity and energy consumption by the brain.
This work has considerable ramifications for the understanding of the origin of the signals detected with the current functional brain imaging techniques used in neurological and psychiatric research (see for example Magistretti et al, Science, 283: 496 497, 1999). He is the author of over 100 articles published in peer-reviewed journals.
He has given over 80 invited lectures at international meetings or at universities in Europe and North America, including the 2000 Talairach Lecture at the Functional Mapping of the Human Brain Conference. In November 2000 he has been a Mc Donnel Visiting Scholar at Washington University School of Medicine.
Pierre J. Magistretti is the President-Elect (2002 2004) of the Federation of European Neuroscience Societies (FENS) which has a membership of over 15000 European neuroscientists. He has been first president of the Swiss Society for Neuroscience (1997-1999) and the first Chairman of the Department of Neurosciences of the University of Lausanne (1996 1998).
Pierre J. Magistretti is Professor of Physiology (since 1988) at the University of Lausanne Medical School. He has been Vice-Dean of the University of Lausanne Medical School from 1996 to 2000. Pierre Magistretti, is Director of the Brain Mind Institute at EPFL and Director of the Center for Psychiatric Neuroscience of the University of Lausanne and CHUV. He is also Director of the NCCR SYNAPSY "the synaptic bases of mental diseases".
POSITIONS AND HONORS
MAIN POSITION HELD
1988-2004 Professor of Physiology, University of Lausanne Medical School
1996-2000 Vice-Dean for Preclinical Departments, University of Lausanne Medical School
2001-2004 Chairman, Department of Physiology, University of Lausanne Medical School
2004-present Professor and Director, Center for Psychiatric Neuroscience, Department of Psychiatry, University of Lausanne Medical School and Hospitals (UNIL-CHUV) (Joint appointment with EPFL)
2005-2008 Professor and Co-Director, Brain Mind Institute, Federal Institute of Technology (EPFL), Lausanne (Joint appointment with UNIL-CHUV)
2007-present Chairman of the Scientific Advisory Board of Centre dImagerie Biomédicale (CIBM), an Imaging Consortium of the Universities, University Hospitals of Lausanne and Geneva and of Ecole Polytechnique Fédérale de Lausanne
2008-present Professor and Director, Brain Mind Institute, Federal Institute of Technology (EPFL), Lausanne Joint appointment with UNIL-CHUV)
2010-present Director, National Center for Competence in Research (NCCR)
The synaptic bases of mental diseases of the Swiss National Science Foundation
2010-present Secretary General, International Brain Research Organization (IBRO)
MAIN HONORS AND AWARDS
1997 Recipient of the Theodore-Ott Prize of the Swiss Academy of Medical Sciences
2001 Elected Member of Academia Europaea
2001 Elected Member of the Swiss Academy of Medical Sciences, ad personam
2002 Recipient of the Emil Kraepelin Guest Professorship, Max Planck Institute für Psychiatry, Münich
2006 Elected Professor at Collège de France, Paris, International Chair 2007-2008
2009 Goethe Award for Psychoanalytic Scholarship, Canadian Psychological Association
2011 Camillo Golgi Medal Award, Golgi Fondation
2011 Elected Member of the American College of NeuroPsychopharmacology (ACNP)
Anthony Christopher Davison
Anthony Davison has published on a wide range of topics in statistical theory and methods, and on environmental, biological and financial applications. His main research interests are statistics of extremes, likelihood asymptotics, bootstrap and other resampling methods, and statistical modelling, with a particular focus on the first currently. Statistics of extremes concerns rare events such as storms, high winds and tides, extreme pollution episodes, sporting records, and the like. The subject has a long history, but under the impact of engineering and environmental problems has been an area of intense development in the past 20 years. Davison''s PhD work was in this area, in a project joint between the Departments of Mathematics and Mechanical Engineering at Imperial College, with the aim of modelling potential high exposures to radioactivity due to releases from nuclear installations. The key tools developed, joint with Richard Smith, were regression models for exceedances over high thresholds, which generalized earlier work by hydrologists, and formed the basis of some important later developments. This has led to an ongoing interest in extremes, and in particular their application to environmental and financial data. A major current interest is the development of suitable methods for modelling rare spatio-temporal events, particularly but not only in the context of climate change. Likelihood asymptotics too have undergone very substantial development since 1980. Key tools here have been saddlepoint and related approximations, which can give remarkably accurate approximate distribution and density functions even for very small sample sizes. These approximations can be used for wide classes of parametric models, but also for certain bootstrap and resampling problems. The literature on these methods can seem arcane, but they are potentially widely applicable, and Davison wrote a book joint with Nancy Reid and Alessandra Brazzale intended to promote their use in applications. Bootstrap methods are now used in many areas of application, where they can provide a researcher with accurate inferences tailor-made to the data available, rather than relying on large-sample or other approximations of doubtful validity. The key idea is to replace analytical calculations of biases, variances, confidence and prediction intervals, and other measures of uncertainty with computer simulation from a suitable statistical model. In a nonparametric situation this model consists of the data themselves, and the simulation simply involves resampling from the existing data, while in a parametric case it involves simulation from a suitable parametric model. There is a wide range of possibilities between these extremes, and the book by Davison and Hinkley explores these for many data examples, with the aim of showing how and when resampling methods succeed and why they can fail. He was Editor of Biometrika (2008-2017), Joint Editor of Journal of the Royal Statistical Society, series B (2000-2003), editor of the IMS Lecture Notes Monograph Series (2007), Associate Editor of Biometrika (1987-1999), and Associate Editor of the Brazilian Journal of Probability and Statistics (1987 2006). Currently he on the editorial board of Annual Reviews of Statistics and its Applications. He has served on committees of Royal Statistical Society and of the Institute of Mathematical Statistics. He is an elected Fellow of the American Statistical Assocation and of the Institute of Mathematical Statistics, an elected member of the International Statistical Institute, and a Chartered Statistician. In 2009 he was awarded a laurea honoris causa in Statistical Science by the University of Padova, in 2011 he held a Francqui Chair at Hasselt University, and in 2012 he was Mitchell Lecturer at the University of Glasgow. In 2015 he received the Guy Medal in Silver of the Royal Statistical Society and in 2018 was a Medallion Lecturer of the Institute of Mathematical Statistics.
Diego Ghezzi
Prof. Diego Ghezzi holds the Medtronic Chair in Neuroengineering at the School of Engineering at the Ecole Polytechnique Fédérale de Lausanne. He received his M.Sc. in Biomedical Engineering (2004) and Ph.D. in Bioengineering (2008) from Politecnico di Milano. From 2008 to 2013, he completed his postdoctoral training at Istituto Italiano di Tecnologia in Genova at the Department of Neuroscience and Brain Technologies; where he was promoted to Researcher in 2013. In 2015, he was appointed as Tenure-Track Assistant Professor of Bioengineering at the EPFL Center for Neuroprosthetics and Institute of Bioengineering.
Pierre Dillenbourg
Ancien instituteur primaire, Pierre Dillenbourg obtient un master en Sciences de lEducation (Université de Mons, Belgique). Dans son projet de master en 1986, il est l'un des premiers au monde à appliquer les méthodes de 'machine learning' à l'éducation, afin de développer un 'self-improving teaching system'. Ceci lui permettra de débuter une thèse de doctorat en informatique à l'Université de Lancaster (UK) dans le domaine des applications éducatives de lintelligence artificielle. Il a été Maître dEnseignement et de Recherche à lUniversité de Genève. Il rejoint l'EPFL en 2012, où Il fut le directeur du Centre de Recherche sur l'Apprentissage, la formation et ses technologies(CRAFT), puis académique du Centre pour l'Education à l'Ere Digitale (CEDE) qui met en oeuvre la stratégie MOOC de l'EPFL (plus de 2 millions d'inscriptions). Il est actuellement professeur ordinaire en technologies de formation aux sein de la faculté Informatique et Communications et dirige laboratoire d'ergonomie éducative (CHILI). Depuis 2006, il a aussi été le directeur de DUAL-T, la 'leading house' dédiée aux technologies pour les systèmes de formation professionnelle duale. Il a fondé plusieurs start-ups dans l'éducation et rejoint plusieurs conseils d'administration. En 2017, Il a créé avec des collègues le 'Swiss EdTech Collider', un incubateur qui rassemble 80 start-ups dans le domaine des technologies éducatives. En 2018, ils ont lancé LEARN, le centre EPFL pour les sciences de l'apprentissage, lequel regroupe les initiatives locales en innovation éducative. Pierre est un 'inaugural fellow of the International Society of Learning Sciences'. Il est actuellement le Vice-Président Associé pour l'Education à l'EPFL.