Concept

Vaccinia

Publications associées (18)

Microfluidics and cell-free synthetic biology in the development of new diagnostic and therapeutic platforms

In phenylketonuria, absence or malfunction of the phenylalanine hydroxylase enzyme results in toxic accumulation of phenylalanine in the body. An injectable recombinant enzyme therapy was recently approved and has the potential to improve the quality of li ...

EPFL2021

Reusability of filtering facepiece respirators after decontamination through drying and germicidal UV irradiation

Véronique Michaud, David Vernez, Guillaume Suarez, Kiattisak Batsungnoen

Introduction During pandemics, such as the SARS-CoV-2, filtering facepiece respirators plays an essential role in protecting healthcare personnel. The recycling of respirators is possible in case of critical shortage, but it raises the question of the effe ...

2020

Worldwide, tuberculosis (TB) is the leading cause of death due to infection with a single pathogenic agent, Mycobacterium tuberculosis. In the absence of an effective vaccine, new, more powerful antibiotics are required to halt the growing spread of multid ...

AMER SOC MICROBIOLOGY2019

Towards a point-of-care nanoplasmonic biosensor for rapid and multiplexed detection of pathogenic infections

Hatice Altug, Xiaokang Li, Filiz Yesilköy, Alexander Belushkin, Maria Soler Aznar

The implementation of multiplexed point-of-care biosensors is a top priority to address the current epidemic problems originated by widespread pathogenic infections, like those caused by viruses or bacteria. A rapid and accurate detection, identification, ...

SPIE-INT SOC OPTICAL ENGINEERING2018

Sunlight is known to be a pertinent factor governing the infectivity of waterborne viruses in the environment. Sunlight inactivates viruses via endogenous inactivation (promoted by absorption of UVB sunlight by the virus) and exogenous processes (promoted ...

Elsevier2016

Sanitation of virus in human excreta and animal manure: a focus on mechanisms underlying inactivation heterogeneity

Tamar Kohn, Loïc Decrey, Shinobu Kazama, Kai Udert

Water, sanitation and hygiene interventions are among the most significant health interventions addressing the worldwide burden of diarrheal disease and environmental enteropathy. It was recently established that despite an increase in global toilet covera ...

2015

Vaccinia Virus Entry Is Followed by Core Activation and Proteasome-Mediated Release of the Immunomodulatory Effector VH1 from Lateral Bodies

Henning Paul-Julius Stahlberg, Lucia Reh

Host cell entry of vaccinia virus, the prototypic poxvirus, involves a membrane fusion event delivering the viral core and two proteinaceous lateral bodies (LBs) into the cytosol. Uncoating of viral cores is poorly characterized, and the composition and fu ...

Elsevier BV2013

Defining immunogenic domains of viral proteins capable of eliciting a protective immune response is crucial in the development of novel epitope-based prophylactic strategies. This is particularly important for the selective targeting of conserved regions s ...

Hindawi Publishing Corporation2013

RNAi Screening Reveals Proteasome- and Cullin3-Dependent Stages in Vaccinia Virus Infection

Henning Paul-Julius Stahlberg

A two-step, automated, high-throughput RNAi silencing screen was used to identify host cell factors required during vaccinia virus infection. Validation and analysis of clustered hits revealed previously unknown processes during virus entry, including a me ...

Elsevier BV2012

An Optofluidic Nanoplasmonic Biosensor for Direct Detection of Live Viruses from Biological Media

Hatice Altug, Min Huang

Fast and sensitive virus detection techniques which can be rapidly deployed at multiple sites are essential to prevent and control future epidemics and bioterrorism threats In this Letter we demonstrate a label free optofluidic nanoplasmonic sensor that ca ...

2010

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