Concept
Chromosome 13 humain
Publications associées (26)
Whole-genome doubling drives oncogenic loss of chromatin segregation
Elisa Oricchio, Daniele Tavernari, Natalya Katanayeva, Ruxandra-Andreea Lambuta, Juan Diaz Miyar, Giovanni Ciriello
Whole-genome doubling (WGD) is a recurrent event in human cancers and it promotes chromosomal instability and acquisition of aneuploidies(1-8). However, the three-dimensional organization of chromatin in WGD cells and its contribution to oncogenic phenotyp ...
NATURE PORTFOLIO2023Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci
Elisa Oricchio, Daniele Tavernari, Natalya Katanayeva, Stephanie Jocelyne Sungalee, Ruxandra-Andreea Lambuta, Giovanni Ciriello
In cancer cells, enhancer hijacking mediated by chromosomal alterations and/or increased deposition of acetylated histone H3 lysine 27 (H3K27ac) can support oncogene expression. However, how the chromatin conformation of enhancer-promoter interactions is a ...
2021Mesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations
Denis Duboule, Lucille Delisle, Christopher Chase Bolt
Mesomelic dysplasia, a severe shortening and bending of the limb, has been linked to rearrangements in the HoxD cluster in humans and mice. Here the authors engineer a 1 Mb inversion including the HoxD gene cluster and use this model to provide a mechanist ...
NATURE PORTFOLIO2021Effect of Fc Receptor Genetic Diversity on HIV-1 Disease Pathogenesis
Jacques Fellay, Christian Axel Wandall Thorball
Fc receptor (FcR) genes collectively have copy number and allelic polymorphisms that have been implicated in multiple inflammatory and autoimmune diseases. This variation might also be involved in etiology of infectious diseases. The protective role of Fc- ...
2019Multiscale Spatial Organization of RNA Polymerase in Escherichia coli
Nucleic acid synthesis is spatially organized in many organisms. In bacteria, however, the spatial distribution of transcription remains obscure, owing largely to the diffraction limit of conventional light microscopy (200-300 nm). Here, we use photoactiva ...
Cell Press2013