Concept

Perle (artéfact)

Publications associées (35)

High-Density Immobilization of TCEP on Silica Beads for Efficient Disulfide Reduction and Thiol Alkylation in Peptides

Tris-(2-carboxyethyl)phosphine (TCEP) linked to agarose beads is widely used for reducing disulfide bridges in proteins and peptides. The immobilization of TCEP on beads allows efficient removal after reduction to prevent its reaction with alkylating reage ...

Weinheim2023

Development of methods for the synthesis of large combinatorial libraries of macrocyclic compounds

Mischa Schüttel

Macrocycles have raised much interest in the pharmaceutical industry due to their ability to bind challenging targets while often still being able to cross membranes to reach intracellular proteins. However, the development of macrocyclic ligands to new di ...

EPFL2023

Whirling instability of an eccentric coated fibre

François Gallaire, Edouard Boujo, Shahab Eghbali, Ludovic Pierre Gustave Keiser

We study a gravity-driven viscous flow coating a vertical cylindrical fibre. The destabilisation of a draining liquid column into a downward moving train of beads has been linked to the conjunction of the Rayleigh-Plateau and Kapitza instabilities in the l ...

CAMBRIDGE UNIV PRESS2022

Dielectrophoresis detection device

Carlotta Guiducci

A dielectrophoretic detection device comprising a chip, with a flow channel having at least one inlet and one outlet, and at least a detection area configured to detect analytes trapped on functionalised beads flowing within said flow channel, a first and ...

2021

Preparation of Highly Porous Metal-Organic Framework Beads for Metal Extraction from Liquid Streams

Wendy Lee Queen, Emad Oveisi, Daniel Teav Sun, Shuliang Yang, Li Peng, Olga Trukhina, Olga Syzgantseva, Ilia Kochetygov, Anita Justin, Hassan Abedini, Guanchu Lu

Metal-organic frameworks (MOFs) offer great promise in a variety of gas- and liquid-phase separations. However, the excellent performance on the lab scale hardly translates into pilot- or industrial-scale applications due to the microcrystalline nature of ...

AMER CHEMICAL SOC2020

Permeability of textile fabrics with spherical inclusions

Véronique Michaud, Baris Çaglar

We investigated the effect of rigid spherical inclusions such as microcapsules and fillers on the permeability of fabrics by using glass beads as model inclusions. Beads with a range of diameters (40-800 mu m) and volume fractions (2.5-10%) were sieved bet ...

Elsevier2017

Dose-response curve of a microfluidic magnetic bead-based surface coverage sandwich assay

Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Raphaël Etienne Jean Trouillon, Hüseyin Cumhur Tekin

Magnetic micro-and nanoparticles ('magnetic beads') have been used to advantage in many microfluidic devices for sensitive antigen (Ag) detection. Today, assays that use as read-out of the signal the number count of immobilized beads on a surface for quant ...

Elsevier2015

Effect of annealing and silylation on the strength of melt-spun Ni-Mn-Ga fibres and their adhesion to epoxy

Véronique Michaud, Yves Leterrier, Susanne Glock, Edgars Sparnins

Single crystals of ferromagnetic Ni-Mn-Ga shape memory alloys show magnetic-field and stress induced twinning, leading to shape memory. Adaptive composites can thus be produced by embedding single crystalline particles or bamboo-structured Ni-Mn-Ga fibres ...

2014

Neutral solar photo-Fenton degradation of 4-nitrophenol on iron-enriched hybrid montmorillonite-alginate beads (Fe-MABs)

César Pulgarin, Salvatore Barreca

Hybrid montmorillonite-alginate beads (MABs) were prepared by the ion-gelation method from alginate and montmorillonite clay suspension dropped in a calcium chloride solution. Similarly, iron-enriched beads (Fe-MABs) were prepared using iron-exchanged mont ...

Elsevier Science Sa2014

Attomolar protein detection using a magnetic bead surface coverage assay

Martinus Gijs, Matteo Cornaglia, Hüseyin Cumhur Tekin

We demonstrate a microfluidic method for ultra-sensitive protein detection in serum. First, ‘large’ (2.8 μm) antibody-functionalized magnetic beads specifically capture antigen from a serum matrix under active microfluidic mixing. Subsequently, the large b ...

Royal Society of Chemistry2013

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