Concept

Yersinia pestis

Publications associées (26)

Independent Regulation of Type VI Secretion in Vibrio cholerae by TfoX and TfoY

Melanie Blokesch, Sandrine Stutzmann, Noémie Matthey, Lisa Christina Metzger, Tiziana Scrignari, Charles Ulric V Van der Henst

Type VI secretion systems (T6SSs) are nanomachines used for interbacterial killing and intoxication of eukaryotes. Although Vibrio cholerae is a model organism for structural studies on T6SSs, the underlying regulatory network is less understood. A recent ...

Elsevier2016

Mechanistic insight into mycobacterial MmpL protein function

Stewart Cole, Edina Rita Székely

Mycobacterial cell walls are complex structures containing a broad range of unusual lipids, glycolipids and other polymers, some of which act as immunomodulators or virulence determinants. Better understanding of the enzymes involved in export processes wo ...

Wiley-Blackwell2016

Pore-forming toxins: ancient, but never really out of fashion

Françoise Gisou van der Goot Grunberg, Matteo Dal Peraro

Pore-forming toxins (PFTs) are virulence factors produced by many pathogenic bacteria and have long fascinated structural biologists, microbiologists and immunologists. Interestingly, pore-forming proteins with remarkably similar structures to PFTs are fou ...

Nature Publishing Group2016

Structure of the Dodecameric Yersinia enterocolitica Secretin YscC and Its Trypsin-Resistant Core

Henning Paul-Julius Stahlberg, Andreas Engel

The type Ill secretion system machinery, also known as the injectisome, delivers bacterial effector proteins into eukaryotic cells during infection. The outer membrane YscC secretin is a major part of Yersinia enterocolitica's injectisome and is among the ...

Elsevier BV2013

In situ structural analysis of the Yersinia enterocolitica injectisome

Henning Paul-Julius Stahlberg, Matteo Dal Peraro, Marco Stenta, Matteo Thomas Degiacomi

Injectisomes are multi-protein transmembrane machines allowing pathogenic bacteria to inject effector proteins into eukaryotic host cells, a process called type III secretion. Here we present the first three-dimensional structure of Yersinia enterocolitica ...

Elife Sciences Publications Ltd2013

Plague outbreaks in prairie dog populations explained by percolation thresholds of alternate host abundance

Marcel Salathé

Highly lethal pathogens (e.g., hantaviruses, hendra virus, anthrax, or plague) pose unique public-health problems, because they seem to periodically flare into outbreaks before disappearing into long quiescent phases. A key element to their possible contro ...

2010

Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection

Nicola Harris, Andrew J. Macpherson

Anti-helminth immunity involves CD4+ T cells, yet the precise effector mechanisms responsible for parasite killing or expulsion remain elusive. We now report an essential role for antibodies in mediating immunity against the enteric helminth Heligmosomoide ...

2008

A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra

Stewart Cole

Similarities between Mycobacterium tuberculosis phoP-phoR mutants and the attenuated laboratory strain M. tuberculosis H37Ra in terms of morphological and cytochemical properties, lipid content, gene expression and virulence attenuation prompted us to anal ...

2007

The HIV-1 Nef protein and phagocyte NADPH oxidase activation

Didier Trono

Nef, a multifunctional HIV protein, activates the Vav/Rac/p21-activated kinase (PAK) signaling pathway. Given the potential role of this pathway in the activation of the phagocyte NADPH oxidase, we have investigated the effect of the HIV-1 Nef protein on t ...

2002

Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant

Stewart Cole

Mycobacterium microti is a member of the Mycobacterium tuberculosis complex that causes tuberculosis in voles. Most strains of M. microti are harmless for humans, and some have been successfully used as live tuberculosis vaccines. In an attempt to identify ...

2002

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