Concept
Phases of clinical research
Publications associées (87)
Organoids as tools for fundamental discovery and translation-A Keystone Symposia report
Complex three-dimensional in vitro organ-like models, or organoids, offer a unique biological tool with distinct advantages over two-dimensional cell culture systems, which can be too simplistic, and animal models, which can be too complex and may fail to ...
WILEY2022Proteomics of Human Milk: Definition of a Discovery Workflow for Clinical Research Studies
Milk is a complex biological fluid composed mainly of water, carbohydrates, lipids, proteins, and diverse bioactive factors. Human milk represents a unique tailored source of nutrients that adapts during lactation to the specific needs of the developing in ...
2021Neutrophils in the era of immune checkpoint blockade
Etienne Meylan, Julien Robert Rémi Faget
The immune checkpoint blockade-based immunotherapies are revolutionizing cancer management. Tumor-associated neutrophils (TANs) were recently highlighted to have a pivotal role in modulating the tumor microenvironment and the antitumor immune response. How ...
BMJ PUBLISHING GROUP2021Multifocal stimulation of the cerebro-cerebellar loop during the acquisition of a novel motor skill
Friedhelm Christoph Hummel, Takuya Morishita, Elena Beanato, Maximilian Jonas Wessel, Chang-Hyun Park, Philipp Johannes Koch
Transcranial direct current stimulation (tDCS)-based interventions for augmenting motor learning are gaining interest in systems neuroscience and clinical research. Current approaches focus largely on monofocal motorcortical stimulation. Innovative stimula ...
2021Biology and therapeutic targeting of tumour-associated macrophages
Michele De Palma, Tim Beltraminelli
Macrophages sustain tumour progression by facilitating angiogenesis, promoting immunosuppression, and enhancing cancer cell invasion and metastasis. They also modulate tumour response to anti-cancer therapy in pre-clinical models. This knowledge has motiva ...
WILEY2020In vivo evaluation of gene editing and prosthetic strategies to restore vision in small and large animal models of retinal degeneration
Inherited retinal diseases (IRDs) form a group of diverse disorders that lead to the degeneration of the light-sensing cells of the retina: the photoreceptors. IRDs are among the leading causes of blindness in working-age adults living in industrialized co ...
EPFL2020Blood Flow to the Spleen is Altered in a Mouse Model of Spinal Muscular Atrophy
Spinal muscular atrophy (SMA) is a neuromuscular disorder affecting young children. While pre-clinical models of SMA show small spleens, the same is not true in humans. Here, we show by doppler ultrasonography decreased splenic blood flow in Smn(2B/-) mice ...
2020Epitope Mapping and Fine Specificity of Human T and B Cell Responses for Novel Candidate Blood-Stage Malaria Vaccine P27A
Bruno Emanuel Ferreira De Sousa Correia, Che Yang, Daniel Guignard
P27A is a novel synthetic malaria vaccine candidate derived from the blood stage Plasmodium falciparum protein Trophozoite Exported Protein 1 (TEX1/PFF0165c). In phase 1a/1b clinical trials in malaria unexposed adults in Switzerland and in malaria pre-expo ...
2020Delivery, Beam and Range Monitoring in Particle Therapy in a Highly Innovative Integrated Design
The design of a particle therapy system that integrates an innovative beam delivery concept based on a static toroidal gantry and an imaging configuration suitable for beam and online range monitoring is proposed and discussed. Such approach would provide ...
2020Innovative Tools and in vivo Methods for Tuberculosis Drug Discovery and Development
Worldwide, tuberculosis (TB) is the leading cause of death due to a single infectious agent, claiming 1.6 million human lives and causing >10 million new cases in 2017 alone, mostly in low-income regions. The intracellular pathogen Mycobacterium tuberculos ...
EPFL2019