Publications associées à Regulator gene

RDHK Family, Regulators dedicated to Organohalide Respiration - Sequence Diversity and Functional Prediction

Christof Holliger, Julien Maillard, Mathilde Stéphanie Willemin

Organohalide respiration (OHR) is an anaerobic metabolism by which bacteria conserve energy from the use of organohalide molecules as terminal electron acceptors. Because most organohalides of anthropogenic origin are persistent pollutants, the study of ba ...

2019

Increased drug permeability of a stiffened mycobacterial outer membrane in cells lacking MFS transporter Rv1410 and lipoprotein LprG

Georg Fantner, Haig Alexander Eskandarian

The major facilitator superfamily transporter Rv1410 and the lipoprotein LprG (Rv1411) are encoded by a conserved two-gene operon and contribute to virulence in Mycobacterium tuberculosis. Rv1410 was originally postulated to function as a drug efflux pump, ...

WILEY2019

A Comprehensive Drosophila melanogaster Transcription Factor Interactome

Bart Deplancke, Riccardo Dainese, Jean-Daniel Feuz, Sachi Iiyama Inukai

Combinatorial interactions among transcription factors (TFs) play essential roles in generating gene expression specificity and diversity in metazoans. Using yeast 2-hybrid (Y2H) assays on nearly all sequence-specific Drosophila TFs, we identified 1,983 pr ...

CELL PRESS2019

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

Johan Auwerx, Kristina Schoonjans, Bernard Schneider, Graham Knott, Davide D'Amico, Vera Monica Lemos Da Silva, Mario Romani, Hao Li, Vincenzo Sorrentino, Adrienne Joëlle Laurence Mottis, Francesca Potenza

Little information is available about how post-transcriptional mechanisms regulate the aging process. Here, we show that the RNA-binding protein Pumilio2 (PUM2), which is a translation repressor, is induced upon aging and acts as a negative regulator of li ...

CELL PRESS2019

Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes

Denis Duboule, Lucille Delisle, Edgardo Rodriguez Carballo, Nayuta Yakushiji

Background The spatial organization of the mammalian genome relies upon the formation of chromatin domains of various scales. At the level of gene regulation in cis, collections of enhancer sequences define large regulatory landscapes that usually match wi ...

2019

Beyond silence : a functional and evolutionary study of KRAB zinc finger proteins

Pierre-Yves Joseph Laurent Helleboid

Transposable elements (TEs) are genetic units capable of spreading within the genomes of their host. TEs contribute a readily recognizable 45% of the human DNA, reflecting in part their co-option for some as source of protein-coding sequences, for others a ...

EPFL2019

KAP1 is an antiparallel dimer with a functional asymmetry

Didier Trono, Matteo Dal Peraro, Beat Fierz, Davide Demurtas, Maria Josefina Marcaida Lopez, Louise Catherine Bryan, Giulia Fonti, Pierre-Yves Joseph Laurent Helleboid, Alexandra Styliani Kalantzi

KAP1 (KRAB domain-associated protein 1) plays a fundamental role in regulating gene expression in mammalian cells by recruiting different transcription factors and altering the chromatin state. In doing so, KAP1 acts both as a platform for macromolecular i ...

Life Science Alliance, LLC2019

Multilevel regulation of the glass locus during Drosophila eye development

Bart Deplancke, Michael Vincent Frochaux, Abhishek Kumar Mishra

Development of eye tissue is initiated by a conserved set of transcription factors termed retinal determination network (RDN). In the fruit fly Drosophila melanogaster, the zinc-finger transcription factor Glass acts directly downstream of the RDN to contr ...

PUBLIC LIBRARY SCIENCE2019

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Regulator gene

RDHK Family, Regulators dedicated to Organohalide Respiration - Sequence Diversity and Functional Prediction

EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains

Increased drug permeability of a stiffened mycobacterial outer membrane in cells lacking MFS transporter Rv1410 and lipoprotein LprG

A Comprehensive Drosophila melanogaster Transcription Factor Interactome

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes

Beyond silence : a functional and evolutionary study of KRAB zinc finger proteins

KAP1 is an antiparallel dimer with a functional asymmetry

Structural and functional characterisation of the KRAB-domain associated protein 1

Multilevel regulation of the glass locus during Drosophila eye development

Graph Chatbot

Chattez avec Graph Search

A Comprehensive Drosophila melanogaster Transcription Factor Interactome

EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains

RDHK Family, Regulators dedicated to Organohalide Respiration - Sequence Diversity and Functional Prediction

Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes

Increased drug permeability of a stiffened mycobacterial outer membrane in cells lacking MFS transporter Rv1410 and lipoprotein LprG

Multilevel regulation of the glass locus during Drosophila eye development

Structural and functional characterisation of the KRAB-domain associated protein 1

Beyond silence : a functional and evolutionary study of KRAB zinc finger proteins

KAP1 is an antiparallel dimer with a functional asymmetry

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging