Publications associées à 3'-UTR

Diverse cell-specific patterns of alternative polyadenylation in Drosophila

Most genes in higher eukaryotes express isoforms with distinct 3' untranslated regions (3' UTRs), generated by alternative polyadenylation (APA). Since 3' UTRs are predominant locations of post-transcriptional regulation, APA can render such programs condi ...

NATURE PORTFOLIO2022

Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex

Daniel Constam, Benjamin Marcel Daniel Rothé

Molecular left-right (L-R) asymmetry is established at the node of the mouse embryo as a result of the sensing of a leftward fluid flow by immotile cilia of perinodal crown cells and the consequent degradation of Dand5 mRNA on the left side. We here examin ...

NATURE PORTFOLIO2021

Enteric infection induces Lark-mediated intron retention at the 5 ' end of Drosophila genes

Bart Deplancke, Maroun Bou Sleiman, Michael Vincent Frochaux, Dani Osman, Tommaso Andreani

Background RNA splicing is a key post-transcriptional mechanism that generates protein diversity and contributes to the fine-tuning of gene expression, which may facilitate adaptation to environmental challenges. Here, we employ a systems approach to study ...

2020

Generation of a Large Peptide Phage Display Library by Self-Ligation of Whole-Plasmid PCR Product

Christian Heinis, Xudong Kong, Vanessa Carle, Cristina Diaz Perlas, Kaycie Marie Butler

The success of phage display, used for developing target-specific binders based on peptides and proteins, depends on the size and diversity of the library screened, but generating large libraries of phage-encoded polypeptides remains challenging. New pepti ...

2020

ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer

Didier Trono, Bart Deplancke, Julien Léonard Duc, Julie Marie Russeil, Riccardo Dainese, Marco Cassano, Michaël Imbeault, Sunil Kumar Raghav, Petra Catalina Schwalie, Suk Min Jang, Wanze Chen, Evgeniia Pankevich

Krüppel-associated box zinc finger proteins (KZFPs) constitute the largest family of mammalian transcription factors, but most remain completely uncharacterized. While initially proposed to primarily repress transposable elements, recent reports have revea ...

2019

Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each

Lukas Kühn, Giovanna Ambrosini, Barbara Grisoni-Neupert, Philipp Bucher, Ramona Pauchard-Batschulat, Otto Hagenbüchle

Regulation of mRNA stability by RNA-protein interactions contributes significantly to quantitative aspects of gene expression. We have identified potential mRNA targets of the AU-rich element binding protein AUF1. Myc-tagged AUF1 p42 was induced in mouse N ...

PUBLIC LIBRARY SCIENCE2018

A Large-Scale Functional Screen to Identify Epigenetic Repressors of Retrotransposon Expression

Didier Trono, Gabriela Ecco, Helen Mary Rowe

Deposition of epigenetic marks is an important layer of the transcriptional control of retrotransposons, especially during early embryogenesis. Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) are one of the largest families of transcription ...

2016

Influence of Rotational Nucleosome Positioning on Transcription Start Site Selection in Animal Promoters

Giovanna Ambrosini, Philipp Bucher, René Dreos

The recruitment of RNA-Pol-II to the transcription start site (TSS) is an important step in gene regulation in all organisms. Core promoter elements (CPE) are conserved sequence motifs that guide Pol-II to the TSS by interacting with specific transcription ...

Public Library Science2016

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3'-UTR

Meeting our Makers:Uncovering the cis-regulatory activity of transposable elements using statistical learning

Diverse cell-specific patterns of alternative polyadenylation in Drosophila

Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex

Enteric infection induces Lark-mediated intron retention at the 5 ' end of Drosophila genes

Generation of a Large Peptide Phage Display Library by Self-Ligation of Whole-Plasmid PCR Product

ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer

Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each

A Large-Scale Functional Screen to Identify Epigenetic Repressors of Retrotransposon Expression

A two-state activation mechanism controls the histone methyltransferase Suv39h1

Influence of Rotational Nucleosome Positioning on Transcription Start Site Selection in Animal Promoters

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Chattez avec Graph Search

Diverse cell-specific patterns of alternative polyadenylation in Drosophila

A two-state activation mechanism controls the histone methyltransferase Suv39h1

Influence of Rotational Nucleosome Positioning on Transcription Start Site Selection in Animal Promoters

A Large-Scale Functional Screen to Identify Epigenetic Repressors of Retrotransposon Expression

Enteric infection induces Lark-mediated intron retention at the 5 ' end of Drosophila genes

Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex

Generation of a Large Peptide Phage Display Library by Self-Ligation of Whole-Plasmid PCR Product

ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer

Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each