Concept

Produit génique

Publications associées (49)

Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L

TORC1 is a conserved multisubunit kinase complex that regulates many aspects of eukaryotic growth including the biosynthesis of ribosomes. The TOR protein kinase resident in TORC1 is responsive to environmental cues and is potently inhibited by the natural ...

2011

Next generation microfluidic platforms for high-throughput protein biochemistry

Sebastian Maerkl

DNA technologies such as cloning, DNA microarrays, and next generation sequencing have transformed the life sciences. Protein technologies on the other hand have not seen such explosive progress. This is mainly due to the inherent difficulty of working wit ...

Elsevier2011

Structural Identification of Unate-Like Genetic Network Models from Time-Lapse Protein Concentration Measurements

Giancarlo Ferrari Trecate

We consider the problem of learning dynamical models of genetic regulatory networks from time-lapse measurements of gene expression. In our previous work [Porreca et al,Bioinformatics,2010], we described a method for the structural and parametric identific ...

2010

ERAD substrates: Which way out?

Maurizio Molinari, Riccardo Bernasconi

Global folding of polypeptides entering the endoplasmic reticulum ( ER) starts as soon as they emerge from the narrow Sec61 translocon. Attainment of the native structure can take from several minutes to hours, depending on the gene product. Until then, no ...

2010

Identification of parameters and structure of piecewise affine models of genetic networks

Giancarlo Ferrari Trecate

In this paper we consider piecewise affine models of genetic regulatory networks proposed by Glass and Kaufmann in the 70's and discuss a method for their identification. These systems have specific features that must be preserved by the identification pro ...

2009

The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteria

Petr Leiman

The contractile tail of bacteriophage T4 is a molecular machine that facilitates very high viral infection efficiency. Its major component is a tail sheath, which contracts during infection to less than half of its initial length. The sheath consists of 13 ...

2009

CleanEx: new data extraction and merging tools based on MeSH term annotation

Philipp Bucher

The CleanEx expression database (http://www.cleanex.isb-sib.ch) provides access to public gene expression data via unique gene names as well as via experiments biomedical characteristics. To reach this, a dual annotation of both sequences and experiments h ...

Oxford University Press2009

Structural Identification of Piecewise-Linear Models of Genetic Regulatory Networks

Giancarlo Ferrari Trecate

We present a method for the structural identification of genetic regulatory networks (GRNs), based on the use of a class of Piecewise-Linear (PL) models. These models consist of a set of decoupled linear models describing the different modes of operation o ...

Mary Ann Liebert, Inc. 2 Madison Avenue Larchmont, NY 10538 USA2008

Hybrid identification methods for the reconstruction of genetic regulatory networks

Giancarlo Ferrari Trecate

This tutorial paper considers the problem of reconstructing Genetic Regulatory Networks (GRNs) from gene expression measurements. Among various modeling frameworks that have been proposed for these biological systems, we focus on PieceWise Affine (PWA) mod ...

2007

The human RNA surveillance factor UPF1 is required for S phase progression and genome stability

Joachim Lingner

The eukaryotic nonsense-mediated mRNA decay (NMD) pathway degrades mRNAs carrying premature stop codons (PTC). In humans, NMD depends on the RNA- and DNA-dependent 5'-3' helicase UPF1 and six other gene products referred to as SMG1, UPF2, UPF3, EST1A/SMG6, ...

2006

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