Concept

Épanchement pleural

Publications associées (18)

Chemo-manipulation of tumor blood vessels by a metal-based anticancer complex enhances antitumor therapy

Paul Joseph Dyson, Hubert van den Bergh, Tina Riedel

Human pleural mesothelioma is an incurable and chemoresistant cancer. Using a nude mouse xenograft model of human pleural mesothelioma, we show that RAPTA-T, a compound undergoing preclinical evaluation, enhances tumor vascular function by decreasing blood ...

2018

Interstitial fluid pressure: A novel biomarker to monitor photo-induced drug uptake in tumor and normal tissues.

Georges Wagnières, Michaël Bensimon, Matthieu Philippe Emmanuel Zellweger, Xi Wang, Jean Yannis Perentes

Low-dose photodynamic therapy PDT (photoinduction) can modulate tumor vessels and enhance the uptake of liposomal cisplatin (Lipoplatin®) in pleural malignancies. However, the photo-induction conditions must be tightly controlled as overtreatment shuts dow ...

Wiley2017

Treatment of pleural malignancies by photo-induction combined to systemic chemotherapy: Proof of concept on rodent lung tumors and feasibility study on porcine chest cavities

Georges Wagnières, Michaël Bensimon, Elodie Debefve, Laurent Décosterd, Jean Yannis Perentes

Background: Low-dose, Visudyne (R)-mediated photodynamic therapy (photo-induction) was shown to selectively enhance tumor vessel transport causing increased uptake of systemically administered chemotherapy in various tumor types grown on rodent lungs. The ...

Wiley-Blackwell2015

Angiostatic treatment prior to chemo- or photodynamic therapy improves anti-tumor efficacy

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Débora Bonvin, Edoardo Scherrer

Tumor vasculature is known to be poorly organized leading to increased leakage of molecules to the extravascular space. This process can potentially increase interstitial fluid pressure impairing intra-tumoral blood flow and oxygen supply, and can affect d ...

2015

Preclinical comparison of mTHPC and verteporfin for intracavitary photodynamic therapy of malignant pleural mesothelioma

Georges Wagnières

Efficacy and tumour selectivity of photodynamic therapy with two clinically approved sensitizers (mTHPC, verteporfin) were assessed for focal intracavitary photodynamic therapy (PDT) in rodents with malignant pleural mesothelioma (MPM) at recommended drug- ...

Karger2006

Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation

Melody Swartz

Interstitial fluid movement is intrinsically linked to lymphatic drainage. However, their relationship is poorly understood, and associated pathologies are mostly untreatable. In this work we test the hypothesis that bulk tissue fluid movement can be evalu ...

1999

Clinical photodynamic therapy for superficial cancer in the esophagus and the bronchi: 514 nm compared with 630 nm light irradiation after sensitization with Photofrin II

Hubert van den Bergh, Georges Wagnières

Photodynamic therapy (PDT) for cancer in the esophagus and bronchi with red (630 nm) light may occasionally lead to wall perforation and fistula. Therefore, the clin. use of a less penetrating wavelength (514 nm) was investigated for the curative treatment ...

1998

R–502 and Two Near-Azeotropic Alternatives. Part II: Two-Phase Flow Patterns

John Richard Thome, Daniel Favrat

Flow patterns for horizontal intube flow boiling have been studied for the new refrigerants HP80 and HP62 and the conventional refrigerant R-502. The flow pattern observations were compared with several criteria utilized in horizontal flow boiling correlat ...

1995

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