Publications associées à Poliovirus

Observed Kinetics of Enterovirus Inactivation by Free Chlorine Are Host Cell-Dependent

Tamar Kohn, Shannon Christa David, Shotaro Torii, Odile Marie Clotilde Hervás de Nalda-Larivé, Federica Cariti

Virucidal efficacies of disinfectants are typically assessed by infectivity assay utilizing a single type of host cell. Enteroviruses infect multiple host cells via various entry routes, and each entry route may be impaired differently by a given disinfect ...

2023

Numerical simulation of the fate, transport and public health risks of enteric viruses in Lake Geneva

Chaojie Li

Lakes are a fundamental feature of nature with brilliance, profoundness and complexity. Various of physical, chemical and biological changes take place three dimensionally in deep lakes, regulated by complicated boundary conditions. To understand and predi ...

EPFL2023

Selective elimination of enterovirus genotypes by activated sludge and chlorination

Tamar Kohn, Shotaro Torii

Enteroviruses, which are commonly circulating viruses shed in the stool, are released into the sewage system and only partially removed or inactivated, resulting in the discharge of infectious enteroviruses into the environment. Activated sludge and chlori ...

2023

Genotype-Dependent Kinetics of Enterovirus Inactivation by Free Chlorine and Ultraviolet (UV) Irradiation

Tamar Kohn, Shotaro Torii

Inactivation kinetics of enterovirus by disinfection is often studied using a single laboratory strain of a given genotype. Environmental variants of enterovirus are genetically distinct from the corresponding laboratory strain, yet it is poorly understood ...

2022

An integrated cell culture reverse transcriptase quantitative PCR (ICC-RTqPCR) method to simultaneously quantify the infectious concentrations of eight environmentally relevant enterovirus serotypes

Tamar Kohn, Jade Brandani, Odile Marie Clotilde Hervás de Nalda-Larivé, Manupriyam Dubey

Enterovirus (EV) infectivity is typically measured as a bulk parameter, yet EV serotypes vary in their susceptibility to natural and engineered stressors. Here we developed an integrated cell culture reverse transcriptase quantitative PCR (ICC-RTqPCR) meth ...

2021

Novel broad-spectrum virucidal antivirals

Matteo Gasbarri

The current COVID-19 pandemic has showed the threats that viruses can cause to the whole world. Over 200 million infections and over 4.5 million deaths and enormous socio-economic impact were the output of the emergence of a single new pathogen: SARS-CoV-2 ...

EPFL2021

Salt enhances the thermostability of enteroviruses by stabilizing capsid protein interfaces

Tamar Kohn, Matteo Dal Peraro, Simon Meister, Alessio Prunotto

Enteroviruses are common agents of infectious disease that are spread by the fecal-oral route. They are readily inactivated by mild heat, which causes the viral capsid to disintegrate or undergo conformational change. While beneficial for the thermal treat ...

American Society for Microbiology2020

Adaptation of Human Enterovirus to Warm Environments Leads to Resistance against Chlorine Disinfection

Tamar Kohn, Anna Carratala Ripolles, Virginie Bachmann, Timothy R. Julian

Sunlight, temperature, and microbial grazing are among the environmental factors promoting the inactivation of viral pathogens in surface waters. Globally, these factors vary across time and space. The persistence of viral pathogens, and ultimately their e ...

2020

Initial Step of Virus Entry: Virion Binding to Cell-Surface Glycans

Laurent Gillet, Christian Sieben

Virus infection is an intricate process that requires the concerted action of both viral and host cell components. Entry of viruses into cells is initiated by interactions between viral proteins and cell-surface receptors. Various cell-surface glycans func ...

ANNUAL REVIEWS2020

Susceptibility of Enterovirus B strains to disinfectants and heat

Simon Meister

The susceptibility of waterborne viruses to different inactivating treatments is acknowledged to vary between viruses and even between closely related strains, yet the extent of this variation, or the underlying mechanisms, are not known. Here, different e ...

EPFL2019