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Publications associées (20)

Photovoltaic retinal prosthesis restores high-resolution responses to single-pixel stimulation in blind retinas

Diego Ghezzi, Marta Jole Ildelfonsa Airaghi Leccardi, Naïg Aurelia Ludmilla Chenais

Retinal prostheses hold the promise of restoring vision in totally blind people. However, a decade of clinical trials highlighted quantitative limitations hampering the possibility of reaching this goal. A key challenge in retinal stimulation is to indepen ...

2021

Photovoltaic stimulation of retinal microcircuit for vision restoration

Naïg Aurelia Ludmilla Chenais

Sight restoration through retinal prostheses was still a mere dream a century ago. Current challenges are even greater: providing a quantitatively and qualitatively useful artificial vision to late blind patients. Existing approaches all face engineering a ...

EPFL2021

Long-lasting feature integration

In the classic model of vision, processing is local, feedforward and hierarchical. The first stages of the visual system are retinotopic, i.e., neighboring points in the outside world are mapped onto neighboring photoreceptors of the retina and this is pre ...

EPFL2020

Gene Editing Preserves Visual Functions in a Mouse Model of Retinal Degeneration

Diego Ghezzi, Paola Vagni, Naïg Aurelia Ludmilla Chenais, Tommaso Marchetti

Inherited retinal dystrophies (IRDs) are a large and heterogeneous group of degenerative diseases caused by mutations in various genes. Given the favorable anatomical and immunological characteristics of the eye, gene therapy holds great potential for thei ...

2019

Beyond Bouma's window: How to explain global aspects of crowding?

Michael Herzog, Gregory Francis, Adrien Christophe Doerig, Aaron Michael Clarke, Alban Bornet

In crowding, perception of an object deteriorates in the presence of nearby elements. Although crowding is a ubiquitous phenomenon, since elements are rarely seen in isolation, to date there exists no consensus on how to model it. Previous experiments show ...

2019

Insect-Inspired Visual Perception for Flight Control and Collision Avoidance

Julien Jean Denis Nicolas Lecoeur

Flying robots are increasingly used for tasks such as aerial mapping, fast exploration, video footage and monitoring of buildings. Autonomous flight at low altitude in cluttered and unknown environments is an active research topic because it poses challen ...

EPFL2019

Multilevel regulation of the glass locus during Drosophila eye development

Bart Deplancke, Michael Vincent Frochaux, Abhishek Kumar Mishra

Development of eye tissue is initiated by a conserved set of transcription factors termed retinal determination network (RDN). In the fruit fly Drosophila melanogaster, the zinc-finger transcription factor Glass acts directly downstream of the RDN to contr ...

PUBLIC LIBRARY SCIENCE2019

Preservation of visual function in an animal model of retinal degeneration using CRISPR/Cas9 gene editing

Diego Ghezzi, Paola Vagni, Tommaso Marchetti

Aims: Inherited Retinal Disorders represent a difficult target for gene therapy. This study exploits the possibility of using CRISPR/Cas9-based gene editing in photoreceptor progenitors to prevent cell death. We performed all the experiments on Rd10 mice, ...

2018

Validation of a Foldable and Photovoltaic Wide-Field Epiretinal Prosthesis

Diego Ghezzi

Inspired by intra ocular lenses, we designed a foldable and wide-field epiretinal prosthesis capable of achieving a wireless photovoltaic stimulation of retinal ganglion cells with a remarkable increase in its retinal coverage and in the number of stimulat ...

2018

From retinotopic processing to nonretinotopic representation

Marc Michael Lauffs

Encoding of visual information in the brain is retinotopic: Neighboring points in the visual field are mapped onto neighboring photoreceptors in the retina, and these neighborhood relations are maintained in the early stages of cortical processing. However ...

EPFL2017

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