Concept

Biologie médicale

Publications associées (33)

Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer's disease pathology and clinical disease progression

Bénédicte Marie Maréchal, Jonas Richiardi, Christopher Clark

BackgroundTo assess the performance of plasma neurofilament light (NfL) and phosphorylated tau 181 (p-tau181) to inform about cerebral Alzheimer's disease (AD) pathology and predict clinical progression in a memory clinic setting.MethodsPlasma NfL and p-ta ...

BMC2021

Title: "Labels Matter: Is it stress or is it Trauma?"

Maria del Carmen Sandi Perez

In neuroscience, the term 'Stress' has a negative connotation because of its potential to trigger or exacerbate psychopathologies. Yet in the face of exposure to stress, the more common reaction to stress is resilience, indicating that resilience is the ru ...

SPRINGERNATURE2021

Challenges for biophysical modeling of microstructure

Ileana Ozana Jelescu

The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25 years. In this review, we dwell on the various challenges along the journey of bringing a biophysical model from initial design to clinical implementation, identifyi ...

2020

Comparison of gait characteristics between clinical and daily life settings in children with cerebral palsy

Kamiar Aminian, Anisoara Ionescu, Lena Carcreff, Stéphane Armand

Gait assessments in standardized settings, as part of the clinical follow-up of children with cerebral palsy (CP), may not represent gait in daily life. This study aimed at comparing gait characteristics in laboratory and real life settings on the basis of ...

NATURE PUBLISHING GROUP2020

Postural Control and Consciousness and Their Applications to Lower-Limb Exoskeletons

Jemina Fasola

Human postural control requires high coordination and is distributed over the whole musculoskeletal and nervous systems. Hence, postural balance can be impaired due to various pathologies. Efficient rehabilitation programs and technological solutions are t ...

EPFL2020

Low Power Sensing and Processing in Wearable Biomedical Devices for Personalized Health Monitoring

Grégoire Casimir Joseph Surrel

Whether it is for personal use or for medical application, wearable sensors are becoming more and more widespread. This is the industry answer to two parallel trends. First, the public show a wish to collect data about their own lifestyle. This rather new ...

EPFL2019

A biosensor for measuring NAD(+) levels at the point of care

Johan Auwerx, Kai Johnsson, Luc Patiny, Elena Katsyuba, Qiuliyang Yu, Lin Xue

The cellular level of nicotinamide adenine dinucleotide (NAD(+)), through its different functions, affects cellular metabolism and signalling(1-3). A decrease in the NAD(+) content has been associated with various pathologies and physiological aging(4,5), ...

NATURE PUBLISHING GROUP2019

At the Intersection of Microbiota and Circadian Clock: Are Sexual Dimorphism and Growth Hormones the Missing Link to Pathology? Circadian Clock and Microbiota: Potential Egffect on Growth Hormone and Sexual Development

Frédéric Bruno Martin Gachon, Benjamin Dieter Weger

Reciprocal interactions between the host circadian clock and the microbiota are evidenced by recent literature. Interestingly, dysregulation of either the circadian clock or microbiota is associated with common human pathologies such as obesity, type 2 dia ...

WILEY2019

Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay

Hilal Lashuel, Lara Petricca, Sean Michael Deguire

Accumulation and aggregation of misfolded alpha-synuclein is believed to be a cause of Parkinson's disease (PD). Phosphorylation of alpha-synuclein at S129 is known to be associated with the pathological misfolding process, but efforts to investigate the r ...

2019

NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans

Stewart Cole

During active TB in humans a spectrum of pulmonary granulomas with central necrosis and hypoxia exists. BALB/c mice, predominantly used in TB drug development, do not reproduce this complex pathology thereby inaccurately predicting clinical outcome. We fou ...

Nature Publishing Group2017

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