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Publications associées (81)

The Channel-Activating Protease CAP1/Prss8 Is Required for Placental Labyrinth Maturation

Simona Frateschi, Friedrich Beermann, Roch-Philippe Charles, Aline Dousse

The serine protease CAP1/Prss8 is crucial for skin barrier function, lung alveolar fluid clearance and has been unveiled as diagnostic marker for specific cancer types. Here, we show that a constitutive knockout of CAP1/Prss8 leads to embryonic lethality. ...

Public Library of Science2013

Jagged1 is the major regulator of notch-dependent cell fate in proximal airways

Freddy Radtke

Background: The Notch signaling pathway plays complex roles in developing lungs, including regulation of proximodistal fates, airway cell specification and differentiation. However, the specific Notch-mediated signals involved in lung development remain un ...

Wiley-Blackwell2013

Near-Affine-Invariant Texture Learning for Lung Tissue Analysis Using Isotropic Wavelet Frames

Dimitri Nestor Alice Van De Ville, Adrien Raphaël Depeursinge

We propose near-affine-invariant texture descriptors derived from isotropic wavelet frames for the characterization of lung tissue patterns in high-resolution computed tomography (HRCT) imaging. Affine invariance is desirable to enable learning of nondeter ...

Institute of Electrical and Electronics Engineers2012

ERLOTINIB DERIVATIVES & USES THEREOF

Sandrine Gerber, Davide Städler, Solène Marcelle Françoise Marie Passemard, Françoise Borcard, Damien Evéquoz

The present invention relates to compounds useful in the treatment of cancers, in particular cancers overexpressing the epidermal growth factor receptor (EGFR) such as non-small cell lung or breast cancers. ...

2012

Photodynamic therapy enhances liposomal doxorubicin distribution in tumors during isolated perfusion of rodent lungs

Hubert van den Bergh, Elodie Debefve, Yi Wang

Background: Photodynamic therapy (PDT) at low drug-light conditions can enhance the transport of intravenously injected macromolecular therapeutics through the tumor vasculature. Here we determined the impact of PDT on the distribution of liposomal doxorub ...

Karger2011

Cytotoxic effect of a polymer-copper(II) complex containing 2,2 '-bipyridyl ligand on human lung cancer cells

The cytotoxic activity of the polymer-copper(II) complex, [Cu(bpy)(2)(BPEI)]Cl-2 center dot 4H(2)O (bpy = 2,2'-bipyridine, BPEI = branched polyethyleneimine) on NCI-H460 human lung cancer cells was determined adopting MTT assay and specific staining techni ...

2011

Local glucocorticoid production in the mouse lung is induced by immune cell stimulation

Kristina Schoonjans

Background: Glucocorticoids (GC) are potent anti-inflammatory and immunosuppressive steroid hormones, mainly produced by the adrenal glands. However, increasing evidence supports the idea of additional extra-adrenal sources of bioactive GC. The lung epithe ...

Wiley-Blackwell2011

In Vitro Investigation of the Cellular Toxicity of Boron Nitride Nanotubes

László Forró, Arnaud Magrez, Endre Horvath, Rita Smajda, Lenke Horváth, Beat Schwaller

Nanotubes present one of the most promising opportunities in nanotechnology with a plethora of applications in nanoelectronics, mechanical engineering, as well as in biomedical technology. Due to their structure and some physical properties, boron nitride ...

American Chemical Society2011

Detecting small lung tumors in mouse models by refractive-index microradiology

Giorgio Margaritondo

Refractive-index (phase-contrast) radiology was able to detect lung tumors less than 1 mm in live mice. Significant micromorphology differences were observed in the microradiographs between normal, inflamed, and lung cancer tissues. This was made possible ...

Springer Verlag2011

SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas

Squamous cell carcinoma (SCC) of the lung is a frequent and aggressive cancer type. Gene amplifications, a known activating mechanism of oncogenes, target the 3q26-qter region as one of the most frequently gained/amplified genomic sites in SCC of various t ...

Public Library of Science2010

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