Concept

Cell cycle checkpoint

Publications associées (343)

Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts

The transition from quiescence to proliferation is a key regulatory step that can be induced by serum stimulation in cultured fibroblasts. The transcription factor Myc is directly induced by serum mitogens and drives a secondary gene expression program tha ...

2012

Isolation and Analysis of Regulators Coordinating the Nuclear Cycle with Cytokinesis in Schizosaccharomyces Pombe

Evelyn Lattmann

During the division of a mother cell into two daughter cells the genetic material of the mother cell is replicated and segregated to the daughter cells before the cytoplasm divides into two portions in a process called cytokinesis. In order to maintain the ...

EPFL2012

The nucleoporin Nup205/NPP-3 is lost near centrosomes at mitotic onset and can modulate the timing of this process in Caenorhabditis elegans embryos

Pierre Gönczy, Coralie Busso

Regulation of mitosis in time and space is critical for proper cell division. We conducted an RNA interference-based modifier screen to identify novel regulators of mitosis in Caenorhabditis elegans embryos. Of particular interest, this screen revealed tha ...

Amer Soc Cell Biology2012

Integrative Genomics Identifies the Corepressor SMRT as a Gatekeeper of Adipogenesis through the Transcription Factors C/EBPβ and KAISO

Bart Deplancke, Sebastian Martin Waszak, Sunil Kumar Raghav, Alina Isakova, Irina Krier

The molecular role of corepressors is poorly understood. Here, we studied the transcriptional function of the corepressor SMRT during terminal adipogenesis. Genome-wide DNA-binding profiling revealed that this corepressor is predominantly located in active ...

2012

Analysis of centriole elimination during C. elegans oogenesis

Pierre Gönczy, Graham Knott, Petr Strnad, Lukas von Tobel, Tamara Mikeladze-Dvali

Centrosomes are the principal microtubule organizing centers (MTOCs) of animal cells and comprise a pair of centrioles surrounded by pericentriolar material (PCM). Centriole number must be carefully regulated, notably to ensure bipolar spindle formation an ...

2012

Predicting stem cell fate changes by differential cell cycle progression patterns

Matthias Lütolf, Daniel Sage, Daniel Andreas Schmitter, Yuya Okawa, Marlen Knobloch

Stem cell self-renewal, commitment and reprogramming rely on a poorly understood coordination of cell cycle progression and execution of cell fate choices. Using existing experimental paradigms, it has not been possible to probe this relationship systemati ...

Company of Biologists2012

Notch1 mediates uterine stromal differentiation and is critical for complete decidualization in the mouse

Freddy Radtke

Uterine receptivity implies a dialogue between the hormonally primed maternal endometrium and the free-floating blastocyst. Endometrial stromal cells proliferate, avert apoptosis, and undergo decidualization in preparation for implantation; however, the mo ...

Federation of American Society of Experimental Biology2012

Lrig1: a new master regulator of epithelial stem cells

Paloma Ordonez Moran

The intestine represents the most vigorously renewing, adult epithelial tissue that makes maintenance of its homeostasis a delicate balance between proliferation, cell cycle arrest, migration, differentiation, and cell death. These processes are precisely ...

2012

Zebrafish hmx1 promotes retinogenesis

Ocular development is controlled by a complex network of transcription factors, cell cycle regulators, and diffusible signaling molecules. Together, these molecules regulate cell proliferation, apoptosis and specify retinal fate. In the zebrafish (Danio re ...

Academic Press Ltd- Elsevier Science Ltd2012

The human CST complex is a terminator of telomerase activity

Joachim Lingner, Sophie Redon, Liuh-Yow Chen

The lengths of human telomeres, which protect chromosome ends from degradation and end fusions(1,2), are crucial determinants of cell lifespan(3). During embryogenesis and in cancer, the telomerase enzyme counteracts telomeric DNA shortening. As shown in c ...

Nature Publishing Group2012

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