Concept
Genetic engineering techniques
Publications associées (81)
Computational design of anti-CRISPR proteins with improved inhibition potency
Bruno Emanuel Ferreira De Sousa Correia, Sandrine Madeleine Suzanne Georgeon, Zander Harteveld, Andreas Scheck, Wei Sun, Stéphane Rosset, Julius Valten Upmeier Zu Belzen, Yujia Wang
Anti-CRISPR (Acr) proteins are powerful tools to control CRISPR-Cas technologies. However, the available Acr repertoire is limited to naturally occurring variants. Here, we applied structure-based design on AcrIIC1, a broad-spectrum CRISPR-Cas9 inhibitor, ...
NATURE PUBLISHING GROUP2020Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy
Henning Paul-Julius Stahlberg, Thomas Hofer, Wei Xu
Endogenous costimulatory molecules on T cells such as 4-1BB (CD137) can be leveraged for cancer immunotherapy. Systemic administration of agonistic anti-4-1BB antibodies, although effective preclinically, has not advanced to phase 3 trials because they hav ...
American Association for the Advancement of Science (AAAS)2019