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Increased life expectancy goes hand in hand with a higher incidence of age-related diseases that affect the nervous and metabolic systems, such as type 2 diabetes, cancer, Parkinson’s and Alzheimer’s disease. These complex diseases are a product of the com ...
We introduce a flexible and robust simulation-based framework to infer demographic parameters from the site frequency spectrum (SFS) computed on large genomic datasets. We show that our composite-likelihood approach allows one to study evolutionary models ...
We compare the structural properties of the street networks of ten different European cities using their primal representation. We investigate the properties of the geometry of the networks and a set of centrality measures highlighting differences and simi ...
Nonlinear dynamical systems have been used in many disciplines to model complex behaviors, including biological motor control, robotics, perception, economics, traffic prediction, and neuroscience. While often the unexpected emergent behavior of nonlinear ...
This paper presents a methodology to perform design space exploration of complex signal processing systems implemented using the CAL dataflow language. In the course of space exploration, critical path in dataflow programs is first presented, and then anal ...
This paper proposes a simulation-based optimization (SO) method that enables the efficient use of complex stochastic urban traffic simulators to address various transportation problems. It presents a metamodel that integrates information from a simulator w ...
Genomic analyses often involve scanning for potential transcription factor (TF) binding sites using models of the sequence specificity of DNA binding proteins. Many approaches have been developed to model and learn a protein's DNA-binding specificity, but ...
Multiview video with interactive and smooth view switching at the receiver is a challenging application with several issues in terms of effective use of storage and bandwidth resources, reactivity of the system, quality of the viewing experience and system ...
The connectedness percolation threshold (eta(c)) and critical coordination number (Z(c)) of systems of penetrable spherocylinders characterized by a length polydispersity are studied by way of Monte Carlo simulations for several aspect ratio distributions. ...
For the past century, the urban underground has been developed piecemeal rather than as the object of a long-term planning effort. There is a growing awareness by urban planners and engineers that the underground contains not only potential usable space, b ...