Concept

Plasmodium berghei

Publications associées (74)

Directed Biosynthesis of Phytotoxic Alkaloids in the Cyanobacterium Nostoc 78-12A

Cyril Portmann, Karl Gademann, Cora Prestinari, Theresa Myers

Nostocarboline, a chlorinated and N-methylated carbolinium alkaloid, displays potent and selective inhibition of photoautotrophic organisms as well as the malaria parasite Plasmodium falciparum, while showing very low toxicity to bacterial and fungal patho ...

2009

Antimalarial natural products of marine and freshwater origin

Karl Gademann, Joanna Kobylinska

This review highlights recently discovered antimalarial natural products from marine and freshwater sources described in the literature from 2006 to 2008. The structures as well as bioactivities of compounds against the malaria parasites such as Plasmodium ...

2009

Functional analysis of protein kinase CK2 of the human malaria parasite Plasmodium falciparum

Protein kinase CK2 (casein kinase 2) is a eukaryotic serine/threonine protein kinase with multiple substrates and roles in diverse cellular processes, including differentiation, proliferation, and translation. The mammalian holoenzyme consists of two catal ...

American Society for Microbiology2009

New antiplasmodial natural products from cyanobacteria: linking their ecological role to their therapeutic potential

Cyril Portmann, Karl Gademann

Cyanobacteria (blue-green algae) produce many metabolites that are directed towards competing photoautotrophs. Such algicidal compounds might offer new approaches for the selective inhibition of the malaria parasite, Plasmodium falciparum, as this organism ...

2009

Signalling in malaria parasites. The MALSIG consortium.

Ashish Sharma

Depending on their developmental stage in the life cycle, malaria parasites develop within or outside host cells, and in extremely diverse contexts such as the vertebrate liver and blood circulation, or the insect midgut and hemocoel. Cellular and molecula ...

2009

PfeIK1, a eukaryotic initiation factor 2alpha kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation

BACKGROUND: Post-transcriptional control of gene expression is suspected to play an important role in malaria parasites. In yeast and metazoans, part of the stress response is mediated through phosphorylation of eukaryotic translation initiation factor 2al ...

BioMed Central2009

Proteins interacting with PfEMP1 in P. falciparum infected erythrocyte

Damien Jacot

During infection in humans, P. falciparum invades and refurbishes the red blood cells (RBCs) in order to persist and proliferate. Parasite survival depends on expression of a parasite encoded cytoadherence ligand at the surface of the infected RBC called P ...

2009

Disruption of the PfPK7 gene impairs schizogony and sporogony in the human malaria parasite Plasmodium falciparum

PfPK7 is an orphan protein kinase of Plasmodium falciparum with maximal homology to MEK3/6 and to fungal protein kinase A proteins in its C-terminal and N-terminal regions, respectively. We showed previously that recombinant PfPK7 is active on various subs ...

American Society for Microbiology2008

Plasmodium falciparum regulatory subunit of cAMP-dependent PKA and anion channel conductance

Malaria symptoms occur during Plasmodium falciparum development into red blood cells. During this process, the parasites make substantial modifications to the host cell in order to facilitate nutrient uptake and aid in parasite metabolism. One significant ...

Public Library of Science2008

A comprehensive model of purine uptake by the malaria parasite Plasmodium falciparum: identification of four purine transport activities in intraerythrocytic parasites

Plasmodium falciparum is incapable of de novo purine biosynthesis, and is absolutely dependent on transporters to salvage purines from the environment. Only one low-affinity adenosine transporter has been characterized to date. In the present study we repo ...

Portland Press2008

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